Evidence map›Paper›PMID 38979417›Full record

ArticleFrontiers in immunology2024

The effect of exercise and disease status on mobilization of anti-tumorigenic and pro-tumorigenic immune cells in women with breast cancer.

Tiia Koivula, Salla Lempiäinen, Joona Neuvonen, Jooa Norha, Maija Hollmén, Carl Johan Sundberg, Helene Rundqvist, Heikki Minn, Petteri Rinne, Ilkka Heinonen

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Physical Exercise in Immunotherapy.Sports medicine - open · 2026
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  5. Exercise and CD8Journal of molecular medicine (Berlin, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tiia KoivulaTurku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
Salla LempiäinenTurku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
Joona NeuvonenTurku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
Jooa NorhaTurku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
Maija HollménMediCity Research Laboratory, University of Turku, Turku, Finland.
Carl Johan SundbergDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Helene RundqvistDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Heikki MinnDepartment of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland.
Petteri RinneInstitute of Biomedicine, University of Turku, Turku, Finland.
Ilkka HeinonenTurku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mobilization of certain immune cells may improve the ability of the immune system to combat tumor cells, but the effect of acute exercise on mobilizing immune cells has been sparsely investigated in cancer patients. Therefore, we examined how acute exercise influences circulating immune cells in breast cancer patients. Methods: Nineteen newly diagnosed breast cancer patients aged 36-68 performed 30 minutes of moderate-intensity exercise with a cycle ergometer. Blood samples were collected at various time points: at rest, at 15 (E15) and 30 minutes (E30) after onset of the exercise, and at 30 and 60 minutes post-exercise. We analyzed several immune cell subsets using flow cytometry. Results: Acute exercise increased the number of total leukocytes, neutrophils, lymphocytes, monocytes, basophils, total T-cells, CD4 Conclusion: The findings show that the proportions of CD8

Indexed as

Breast NeoplasmsExerciseKiller Cells, NaturalAdultAgedFemaleHumansMiddle AgedMyeloid-Derived Suppressor Cellsacute exercisebreast cancerimmune cellimmunityphysical activitywhite blood cell

Identifiers

PMID38979417
PMCPMC11228136

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.