Evidence map›Paper›PMID 38979410›Full record

ArticleFrontiers in immunology2024

Emerging role of C5aR2: novel insights into the regulation of uterine immune cells during pregnancy.

Fenna Froehlich, Konstanze Landerholm, Johanna Neeb, Ann-Kathrin Meß, Daniel Leonard Seiler, Tamara Tilburgs, Christian Marcel Karsten

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fenna FroehlichInstitute for Systemic Inflammation Research (ISEF), University of Lübeck, Luebeck, Germany.
Konstanze LanderholmInstitute for Systemic Inflammation Research (ISEF), University of Lübeck, Luebeck, Germany.
Johanna NeebInstitute for Systemic Inflammation Research (ISEF), University of Lübeck, Luebeck, Germany.
Ann-Kathrin MeßInstitute for Systemic Inflammation Research (ISEF), University of Lübeck, Luebeck, Germany.
Daniel Leonard SeilerInstitute for Systemic Inflammation Research (ISEF), University of Lübeck, Luebeck, Germany.
Tamara TilburgsDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Christian Marcel KarstenInstitute for Systemic Inflammation Research (ISEF), University of Lübeck, Luebeck, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy is a fascinating immunological phenomenon because it allows allogeneic fetal and placental tissues to survive inside the mother. As a component of innate immunity with high inflammatory potential, the complement system must be tightly regulated during pregnancy. Dysregulation of the complement system plays a role in pregnancy complications including pre-eclampsia and intrauterine growth restriction. Complement components are also used as biomarkers for pregnancy complications. However, the mechanisms of detrimental role of complement in pregnancy is poorly understood. C5a is the most potent anaphylatoxin and generates multiple immune reactions via two transmembrane receptors, C5aR1 and C5aR2. C5aR1 is pro-inflammatory, but the role of C5aR2 remains largely elusive. Interestingly, murine NK cells have been shown to express C5aR2 without the usual co-expression of C5aR1. Furthermore, C5aR2 appears to regulate IFN-γ production by NK cells

Indexed as

Killer Cells, NaturalMice, KnockoutReceptor, Anaphylatoxin C5aUterusAnimalsComplement C5aFemaleHumansInterferon-gammaMiceMice, Inbred C57BLPlacentaPregnancyC5aR2 protein, humanC5ar2 protein, mouseComplement C5aInterferon-gammaReceptor, Anaphylatoxin C5aanaphylatoxinsC5aR2INF-γpregnancyuterine DCsuterine NK cells

Identifiers

PMID38979410
PMCPMC11229525

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.