Evidence map›Paper›PMID 38979391›Full record

ArticlebioRxiv : the preprint server for biology2024

The pathogenicity of

Lei Liu, Stephanie A Schultz, Adriana Saba, Hyun-Sik Yang, Amy Li, Dennis J Selkoe, Jasmeer P Chhatwal

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Stephanie A Schultz
Adriana Saba
Amy Li
Dennis J Selkoe
Jasmeer P Chhatwal

Funding

Identifying variations in gamma-secretase function that are critical determinants of clinical and biomarker progression of Autosomal Dominant Alzheimer's disease: From mechanism to clinical trialsK01AG084816 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Stephanie Schultz · 2024 to 2026
$387k
NIA NIH HHS K01 AG084816
6 · The paper itself

Abstract

introductionThough recognized as a potential cause of Autosomal Dominant Alzheimer's Disease, the pathogenicity of many

methodsWe expressed 74

resultsAβ42/40 and Aβ37/42 ratios were associated with AAO across DISCUSSION: The existence of a

Identifiers

PMID38979391
PMCPMC11230249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.