Evidence map›Paper›PMID 38979323›Full record

ArticlebioRxiv : the preprint server for biology2024

Structure-Mechanics Principles and Mechanobiology of Fibrocartilage Pericellular Matrix: A Pivotal Role of Type V Collagen.

Chao Wang, Mingyue Fan, Su-Jin Heo, Sheila M Adams, Thomas Li, Yuchen Liu, Qing Li, Claudia Loebel, Farid Alisafaei, Jason A Burdick and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Chao WangSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States.
Mingyue FanSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States.
Su-Jin HeoMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.
Sheila M AdamsDepartment of Molecular Pharmacology and Physiology, Morsani School of Medicine, University of South Florida, Tampa, FL 33612, United States.
Thomas LiSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States.
Yuchen LiuSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States.
Qing LiSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States.
Claudia LoebelDepartment of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, United States.
Farid AlisafaeiDepartment of Mechanical and Industrial Engineering, New Jersey Institute of Technology, Newark, NJ 07102, United States.
Jason A BurdickBioFrontiers Institute and Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80309, United States.
X Lucas LuDepartment of Mechanical Engineering, University of Delaware, Newark, DE 19716, United States.
David E BirkDepartment of Molecular Pharmacology and Physiology, Morsani School of Medicine, University of South Florida, Tampa, FL 33612, United States.
Robert L MauckMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.
Lin HanSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States.

Funding

Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
Dynamic Fibrous Scaffolds for Repairing Dense Connective TissuesR01AR056624 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Jason A Burdick, Robert L Mauck · 2009 to 2026
$7.5M
Mechanical Regulation of Cell Fate and Multi-Scale Function in the Developing MeniscusR01AR075418 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Nathaniel A. Dyment, Lin Han · 2019 to 2026
$4.4M
Biomechanics of Cartilage: Roles of Decorin in ECM Assembly and DegradationR01AR074490 · NIAMS · DREXEL UNIVERSITY · PI Lin Han · 2019 to 2026
$2.3M
Prevention of PTOA via regulation of the cytomechanics of chondrocytesR01AR074472 · NIAMS · UNIVERSITY OF DELAWARE · PI LU, X. LUCAS · 2020 to 2025
$1.5M
NIAMS NIH HHS P30 AR069619NIAMS NIH HHS R01 AR056624NIAMS NIH HHS R01 AR074472NIAMS NIH HHS R01 AR074490NIAMS NIH HHS R01 AR075418
6 · The paper itself

Abstract

The pericellular matrix (PCM) is the immediate microniche surrounding resident cells in various tissue types, regulating matrix turnover, cell-matrix cross-talk and disease initiation. This study elucidated the structure-mechanical properties and mechanobiological functions of the PCM in fibrocartilage, a family of connective tissues that sustain complex tensile and compressive loads in vivo. Studying the murine meniscus as the model tissue, we showed that fibrocartilage PCM contains thinner, random collagen fibrillar networks that entrap proteoglycans, a structure distinct from the densely packed, highly aligned collagen fibers in the bulk extracellular matrix (ECM). In comparison to the ECM, the PCM has a lower modulus and greater isotropy, but similar relative viscoelastic properties. In

Indexed as

collagensfibrocartilagemechanotransductionnanomechanicspericellular matrix

Identifiers

PMID38979323
PMCPMC11230444

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.