Evidence map›Paper›PMID 38979317›Full record

ArticlebioRxiv : the preprint server for biology2024

Destabilized host-parasite dynamics in newly founded populations.

Daniel I Bolnick, Rowan D H Barrett, Emma Choi, Lucas Eckert, Andrew P Hendry, Emily V Kerns, Åsa J Lind, Kathryn Milligan-McClellan, Catherine L Peichel, Kristofer Sasser and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Daniel I BolnickDepartment of Ecology and Evolutionary Biology, University of Connecticut Storrs CT, USA.ORCID 0000-0003-3148-6296
Rowan D H BarrettDepartment of Biology, McGill University, Montreal, Quebec, Canada.
Emma ChoiDepartment of Ecology and Evolutionary Biology, University of Connecticut Storrs CT, USA.
Lucas EckertDepartment of Biology, McGill University, Montreal, Quebec, Canada.
Andrew P HendryDepartment of Biology, McGill University, Montreal, Quebec, Canada.
Emily V KernsDepartment of Integrative Biology, University of Wisconsin, Madison, WI, USA.
Åsa J LindDepartment of Biology, McGill University, Montreal, Quebec, Canada.
Kathryn Milligan-McClellanDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.
Catherine L PeichelDivision of Evolutionary Ecology, Institute of Ecology and Evolution, University of Bern, Bern, Switzerland.
Kristofer SasserDepartment of Integrative Biology, University of Wisconsin, Madison, WI, USA.
Alice R ThorntonCenter for Pathogen Research and Training, University of Massachusetts, Lowell, MA, USA.
Cole WolfDepartment of Integrative Biology, University of Wisconsin, Madison, WI, USA.
Natalie C SteinelCenter for Pathogen Research and Training, University of Massachusetts, Lowell, MA, USA.
Jesse N WeberDepartment of Integrative Biology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0003-4839-6684

Funding

Mining natural infection variation to find the genetic basis of coevolution between vertebrate hosts and helminth parasitesR35GM142891 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WEBER, JESSE NATHANIEL · 2021 to 2025
$1.9M
Determining the Role of the Host Genetic Background on Immune Response and Gut MicrobiotaR15GM122038 · NIGMS · UNIVERSITY OF ALASKA ANCHORAGE · PI MILLIGAN-MCCLELLAN, KATHRYN C.A. · 2017 to 2017
$427k
NIGMS NIH HHS R15 GM122038NIGMS NIH HHS R35 GM142891
6 · The paper itself

Abstract

When species disperse into previously unoccupied habitats, new populations encounter unfamiliar species interactions such as altered parasite loads. Theory predicts that newly founded populations should exhibit destabilized eco-evolutionary fluctuations in infection rates and immune traits. However, to understand founder effects biologists typically rely on retrospective studies of range expansions, missing early-generation infection dynamics. To remedy this, we experimentally founded whole-lake populations of threespine stickleback. Infection rates were temporally stable in native source lakes. In contrast, newly founded populations exhibit destabilized host-parasite dynamics: high starting infection rates led to increases in a heritable immune trait (peritoneal fibrosis), suppressing infection rates. The resulting temporal auto-correlation between infection and immunity suggest that newly founded populations can exhibit rapid host-parasite eco-evolutionary dynamics.

Identifiers

PMID38979317
PMCPMC11230150

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.