Evidence map›Paper›PMID 38979287›Full record

ArticlebioRxiv : the preprint server for biology2024

Neuropathologically-directed profiling of

Gannon A McDonough, Yuchen Cheng, Katherine Morillo, Ryan N Doan, Connor J Kenny, Aaron Foutz, Chae Kim, Mark L Cohen, Brian S Appleby, Christopher A Walsh and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Gannon A McDonoughDivision of Neuropathology, Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0009-0002-8420-9970
Yuchen ChengDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-5903-9773
Katherine MorilloDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Ryan N DoanDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Connor J KennyDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-6328-8935
Aaron FoutzDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Chae KimDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0003-0049-0807
Mark L CohenDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Brian S ApplebyDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Christopher A WalshDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-0156-2238
Jiri G SafarDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
August Yue HuangDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-0416-2854
Michael B MillerDivision of Neuropathology, Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-6205-3314

Funding

VASCULAR, PULMONARY AND RENAL INJURYT32HL007627 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GIMBRONE, MICHAEL A, MITCHELL, RICHARD N · 1985 to 2019
$12.7M
Illuminating neurodegenerative tauopathy from somatic genomic landscapes of single human brain cellsDP2AG086138 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael B Miller · 2023 to 2026
$2.7M
Mechanisms of Somatic Mutation in Alzheimer's Disease Using Single Neuron AnalysisR01AG082346 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael B Miller · 2024 to 2026
$2.7M
Replication mechanism of human prionsR01NS103848 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI SAFAR, JIRI G., SUREWICZ, WITOLD K · 2018 to 2022
$2.6M
Replication mechanism of human prionsR01NS074317 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI SAFAR, JIRI G., SUREWICZ, WITOLD K · 2011 to 2015
$2.6M
Role of clonal somatic mutations in microglia activation and Alzheimer’s diseaseR56AG079857 · NIA · BOSTON CHILDREN'S HOSPITAL · PI HUANG, YUE, LEE, EUNJUNG ALICE · 2023 to 2023
$883k
Genome-Wide Somatic Mutation in Alzheimer's Disease Pathogenesis Using Single Neuron AnalysisK08AG065502 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI MILLER, MICHAEL B · 2020 to 2024
$848k
NCEZID CDC HHS U51 CK000309NHLBI NIH HHS T32 HL007627NIA NIH HHS DP2 AG086138NIA NIH HHS K08 AG065502NIA NIH HHS R01 AG082346NIA NIH HHS R56 AG079857NINDS NIH HHS R01 NS074317NINDS NIH HHS R01 NS103848
6 · The paper itself

Abstract

Creutzfeldt-Jakob Disease (CJD), the most common human prion disease, is associated with pathologic misfolding of the prion protein (PrP), encoded by the

Indexed as

Creutzfeldt-Jakob diseasegeneticsprion diseasePRNPsomatic mutation

Identifiers

PMID38979287
PMCPMC11230391

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.