Evidence map›Paper›PMID 38979285›Full record

ArticlebioRxiv : the preprint server for biology2024

A distinct isoform of Msp300 (nesprin) organizes the perinuclear microtubule organizing center in adipocytes.

Garret M Morton, Maria Pilar Toledo, Chunfeng Zheng, Yiming Zheng, Timothy L Megraw

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Garret M MortonDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL, USA.ORCID 0009-0003-8537-3040
Maria Pilar ToledoDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL, USA.ORCID 0000-0001-5553-6417
Chunfeng ZhengDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL, USA.
Yiming ZhengState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, China, 361102, and Shenzhen Research Institute of Xiamen University, Shenzhen, China, 518057.ORCID 0000-0002-5739-5192
Timothy L MegrawDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL, USA.ORCID 0000-0001-7455-7483

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Centrosomin and Centrosomes in Cell DivisionR01GM068756 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI MEGRAW, TIMOTHY L · 2003 to 2012
$2.8M
Request for administrative supplement to purchase a confocal microscope for project GM139971R01GM139971 · NIGMS · FLORIDA STATE UNIVERSITY · PI MEGRAW, TIMOTHY L · 2021 to 2024
$1.5M
NIGMS NIH HHS R01 GM068756NIGMS NIH HHS R01 GM139971NIH HHS P40 OD018537
6 · The paper itself

Abstract

In many cell types, disparate non-centrosomal microtubule-organizing centers (ncMTOCs) replace functional centrosomes and serve the unique needs of the cell types in which they are formed. In Drosophila fat body cells (adipocytes), an ncMTOC is organized on the nuclear surface. This perinuclear ncMTOC is anchored by Msp300, encoded by one of two nesprin-encoding genes in Drosophila. Msp300 and the spectraplakin short stop (shot) are co-dependent for localization to the nuclear envelope to generate the ncMTOC where they recruit the microtubule minus-end stabilizer Patronin (CAMSAP). The

Identifiers

PMID38979285
PMCPMC11230431

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.