Evidence map›Paper›PMID 38979270›Full record

ArticlebioRxiv : the preprint server for biology2024

Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia.

Meghraj S Baghel, Grace D Burns, Margarita Tsapatsis, Aswathy Peethambaran Mallika, Anna Lourdes F Cruz, Tianyu Cao, Xiaoke K Chen, Isabel De La Rosa, Shaelyn R Marx, Yingzhi Ye and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Meghraj S BaghelDepartment of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA.
Grace D BurnsDepartment of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA.
Margarita TsapatsisDepartment of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA.
Aswathy Peethambaran MallikaDepartment of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA.
Anna Lourdes F CruzDepartment of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA.
Tianyu CaoDepartment of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA.
Xiaoke K ChenDepartment of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA.
Isabel De La RosaDepartment of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA.
Shaelyn R MarxDepartment of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA.
Yingzhi YeDepartment of Physiology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA.
Shuying SunDepartment of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA.
Tong LiDepartment of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA.
Philip C WongDepartment of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA.ORCID 0000-0001-8162-3274

Funding

Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3M
Regulation mechanism and functional genomics of LINE1 RNA in TDP-43 linked neurodegenerationR01AG078948 · NIA · JOHNS HOPKINS UNIVERSITY · PI Xianjun Dong, Shuying Sun · 2022 to 2026
$4.2M
TDP-43 Proteinopathy in ALS-FTD: Mechanism, Target Validation and BiomarkerR01NS095969 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PHILIP C WONG · 2016 to 2026
$2.4M
Generation and characterization of a mouse model exhibiting beta-amyloidosis and tauopathy with nuclear depletion of TDP-43R61NS115161 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WONG, PHILIP C · 2019 to 2019
$2.2M
The role of m6A RNA methylation in C9ORF72-ALS/FTDRF1NS127925 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING · 2022 to 2024
$2.0M
Generation and characterization of a mouse model exhibiting beta-amyloidosis and tauopathy with nuclear depletion of TDP-43R33NS115161 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WONG, PHILIP C · 2022 to 2023
$1.3M
Characterizing novel Mixed Etiology Dementia models compromised for TDP-43 functionF31NS135935 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Grace D Burns · 2024 to 2026
$125k
NIA NIH HHS P30 AG066507NIA NIH HHS R01 AG078948NINDS NIH HHS F31 NS135935NINDS NIH HHS R01 NS095969NINDS NIH HHS R33 NS115161NINDS NIH HHS R61 NS115161NINDS NIH HHS RF1 NS127925
6 · The paper itself

Abstract

TDP-43 proteinopathy, initially disclosed in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), coexists with tauopathy in a variety of neurodegenerative disorders, termed multiple etiology dementias (MEDs), including Alzheimer's Disease (AD). While such co-pathology of TDP-43 is strongly associated with worsened neurodegeneration and steeper cognitive decline, the pathogenic mechanism underlying the exacerbated neuron loss remains elusive. The loss of TDP-43 splicing repression that occurs in presymptomatic ALS-FTD individuals suggests that such early loss could facilitate the pathological conversion of tau to accelerate neuron loss. Here, we report that the loss of TDP-43 repression of cryptic exons in forebrain neurons (

Indexed as

Alzheimer’s DiseaseCaspaseco-pathologyFTDMEDmouse modelNeurodegenerationTauTauopathyTDP-43vulnerable neuron

Identifiers

PMID38979270
PMCPMC11230425

What OpenQuestion holds

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LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.