Evidence map›Paper›PMID 38979225›Full record

ArticlebioRxiv : the preprint server for biology2024

Methionine Restriction Reduces Lung Cancer Progression and Increases Chemotherapy Response.

Kassandra J Naughton, Xiulong Song, Avery R Childress, Erika M Skaggs, Aria L Byrd, Christian M Gosser, Dave-Preston Esoe, Tanner J DuCote, Daniel R Plaugher, Alexsandr Lukyanchuk and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Genes, fuel, and fate in lung cancer.Biochemical Society transactions · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kassandra J NaughtonDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington KY 40536.
Xiulong SongDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington KY 40536.
Avery R ChildressDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington KY 40536.
Erika M SkaggsDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington KY 40536.
Aria L ByrdDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington KY 40536.
Christian M GosserDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington KY 40536.
Dave-Preston EsoeDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington KY 40536.
Tanner J DuCoteDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington KY 40536.
Daniel R PlaugherDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington KY 40536.
Alexsandr LukyanchukDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington KY 40536.
Ryan A GoettlMarkey Cancer Center, University of Kentucky, Lexington KY 40536.
Jinpeng LiuMarkey Cancer Center, University of Kentucky, Lexington KY 40536.
Christine F BrainsonDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington KY 40536.ORCID 0000-0002-0854-5043

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Jennifer F Rogers · 2013 to 2026
$38.3M
University of Kentucky Center for Cancer MetabolismP20GM121327 · NIGMS · UNIVERSITY OF KENTUCKY · PI Binhua P Zhou · 2017 to 2026
$25.0M
Institutional Career Development CoreKL2TR001996 · NCATS · UNIVERSITY OF KENTUCKY · PI BUSH, MATTHEW LEE, KELLY, THOMAS H. · 2016 to 2025
$7.1M
TRAINING GRANT IN MOLECULAR MECHANISMS OF TOXICITY.T32ES007266 · NIEHS · UNIVERSITY OF KENTUCKY · PI LIU, XIAOQI, MELLON, ISABEL W · 1990 to 2020
$3.7M
Interdisciplinary Research Training in Cancer BiologyT32CA165990 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers, KATHLEEN L. O'CONNOR · 2013 to 2026
$3.2M
Targeting Epigenetic Heterogeneity to Improve Lung Cancer Immunotherapy ResponseR01CA237643 · NCI · UNIVERSITY OF KENTUCKY · PI BRAINSON, CHRISTINE FILLMORE · 2019 to 2023
$1.9M
NCATS NIH HHS KL2 TR001996NCI NIH HHS P30 CA177558NCI NIH HHS R01 CA237643NCI NIH HHS T32 CA165990NIEHS NIH HHS T32 ES007266NIGMS NIH HHS P20 GM121327
6 · The paper itself

Abstract

Targeting tumor metabolism through dietary interventions is an area of growing interest, and may help to improve the significant mortality of aggressive cancers, including non-small cell lung cancer (NSCLC). Here we show that the restriction of methionine in the aggressive KRAS

Identifiers

PMID38979225
PMCPMC11230185

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.