Evidence map›Paper›PMID 38979173›Full record

ArticlebioRxiv : the preprint server for biology2024

Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain.

Kevin C Lister, Calvin Wong, Sonali Uttam, Marc Parisien, Patricia Stecum, Nicole Brown, Weihua Cai, Mehdi Hooshmandi, Ning Gu, Mehdi Amiri and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Kevin C ListerDepartment of Anesthesia, McGill University, Montreal, QC, Canada.
Calvin WongDepartment of Anesthesia, McGill University, Montreal, QC, Canada.
Sonali UttamDepartment of Anesthesia, McGill University, Montreal, QC, Canada.
Marc ParisienDepartment of Anesthesia, McGill University, Montreal, QC, Canada.ORCID 0000-0003-2924-5960
Patricia StecumDepartment of Anesthesia, McGill University, Montreal, QC, Canada.
Nicole BrownDepartment of Anesthesia, McGill University, Montreal, QC, Canada.
Weihua CaiDepartment of Anesthesia, McGill University, Montreal, QC, Canada.
Mehdi HooshmandiDepartment of Anesthesia, McGill University, Montreal, QC, Canada.
Ning GuDepartment of Anesthesia, McGill University, Montreal, QC, Canada.
Mehdi AmiriDepartment of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Canada.
Francis BeaudryDépartement de biomédecine vétérinaire, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada.ORCID 0000-0001-5403-7333
Seyed Mehdi JafarnejadPatrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, BT9 7AE, UK.ORCID 0000-0002-5129-7081
Diana Tavares-FerreiraDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Dallas, 75080.ORCID 0000-0003-0986-3630
Nikhil Nageshwar InturiDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Dallas, 75080.
Khadijah MazharDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Dallas, 75080.
Hien T ZhaoIonis Pharmaceuticals, Inc., Carlsbad, CA, USA.
Bethany FitzsimmonsIonis Pharmaceuticals, Inc., Carlsbad, CA, USA.
Christos G GkogkasBiomedical Research Institute, Foundation for Research and Technology-Hellas, University Campus, 45110 Ioannina, Greece.ORCID 0000-0001-6281-3419
Nahum SonenbergDepartment of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Canada.ORCID 0000-0002-4707-8759
Theodore J PriceDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Dallas, 75080.ORCID 0000-0002-6971-6221
Luda DiatchenkoDepartment of Anesthesia, McGill University, Montreal, QC, Canada.
Yaser AtlasiPatrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, BT9 7AE, UK.
Jeffrey S MogilDepartment of Anesthesia, McGill University, Montreal, QC, Canada.
Arkady KhoutorskyDepartment of Anesthesia, McGill University, Montreal, QC, Canada.ORCID 0000-0003-3846-8728

Funding

Translation Control of Pain PlasticityR01NS065926 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI PRICE, THEODORE J. · 2010 to 2023
$5.7M
Medical Research Council MR/X008517/1NINDS NIH HHS R01 NS065926
6 · The paper itself

Abstract

Sensitization of spinal nociceptive circuits plays a crucial role in neuropathic pain. This sensitization depends on new gene expression that is primarily regulated via transcriptional and translational control mechanisms. The relative roles of these mechanisms in regulating gene expression in the clinically relevant chronic phase of neuropathic pain are not well understood. Here, we show that changes in gene expression in the spinal cord during the chronic phase of neuropathic pain are substantially regulated at the translational level. Downregulating spinal translation at the chronic phase alleviated pain hypersensitivity. Cell-type-specific profiling revealed that spinal inhibitory neurons exhibited greater changes in translation after peripheral nerve injury compared to excitatory neurons. Notably, increasing translation selectively in all inhibitory neurons or parvalbumin-positive (PV

Indexed as

mRNA translationneuropathic painparvalbumin interneuronsspinal cord

Identifiers

PMID38979173
PMCPMC11230214

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.