Evidence map›Paper›PMID 38979155›Full record

ArticlebioRxiv : the preprint server for biology2025

The Alzheimer's disease gene

Swati Mishra, Nader Morshed, Sonia Sindhu, Chizuru Kinoshita, Beth Stevens, Suman Jayadev, Jessica E Young

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Swati MishraDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.
Nader MorshedBoston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA.
Sonia SindhuDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.
Chizuru KinoshitaDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.
Beth StevensBoston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA.ORCID 0000-0003-4226-1201
Suman JayadevInstitute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA.
Jessica E YoungDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.ORCID 0000-0003-2106-0339

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Thomas J. Grabowski · 2020 to 2026
$29.0M
Probing the role of SORL1 and endosomal network genetic variation on Alzheimer's disease phenotypes in human neurons.R01AG062148 · NIA · UNIVERSITY OF WASHINGTON · PI YOUNG, JESSICA ELAINE · 2018 to 2022
$3.2M
Characterization of AD-related endolysosomal dysfunction in human neural cellsR01AG080585 · NIA · UNIVERSITY OF WASHINGTON · PI SUMAN JAYADEV, Jessica E Young · 2024 to 2026
$2.5M
Molecular impact of endolysosomal dysfunction on neuron-glia communication pathwaysF32AG079666 · NIA · BOSTON CHILDREN'S HOSPITAL · PI MORSHED, NADER FRANCIS · 2022 to 2025
$164k
NIA NIH HHS F32 AG079666NIA NIH HHS P30 AG066509NIA NIH HHS R01 AG062148NIA NIH HHS R01 AG080585NIDDK NIH HHS P30 DK017047
6 · The paper itself

Abstract

The

Indexed as

Alzheimer’s diseasehiPSC-derived microglialysosomesphagocytosisSORL1

Identifiers

PMID38979155
PMCPMC11230436

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.