Evidence map›Paper›PMID 38979153›Full record

ArticlebioRxiv : the preprint server for biology2024

CD11c-expressing microglia are transient, driven by interactions with apoptotic cells.

Nathaniel Ghena, Sarah R Anderson, Jacqueline M Roberts, Emmalyn Irvin, Joon Schwakopf, Alejandra Bosco, Monica L Vetter

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Nathaniel GhenaDepartment of Neurobiology, University of Utah School of Medicine.ORCID 0000-0003-1890-8036
Sarah R AndersonDepartment of Neurobiology, University of Utah School of Medicine.ORCID 0000-0002-7639-4064
Jacqueline M RobertsDepartment of Neurobiology, University of Utah School of Medicine.ORCID 0000-0002-1024-3976
Emmalyn IrvinDepartment of Neurobiology, University of Utah School of Medicine.
Joon SchwakopfDepartment of Neurobiology, University of Utah School of Medicine.ORCID 0000-0002-4907-6028
Alejandra BoscoDepartment of Neurobiology, University of Utah School of Medicine.ORCID 0000-0003-3743-5414
Monica L VetterDepartment of Neurobiology, University of Utah School of Medicine.ORCID 0000-0001-6262-8504

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Developmental Regulation of Retinal MicrogliaR01EY030307 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Monica L Vetter · 2019 to 2026
$2.9M
Vision Research Training Grant at the University of UtahT32EY024234 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI DAVID KRIZAJ, Monica L Vetter · 2014 to 2026
$2.3M
The Neuroimmunology Training Program at the University of UtahT32NS115664 · NINDS · UNIVERSITY OF UTAH · PI O'CONNELL, RYAN M, WILCOX, KAREN S · 2020 to 2024
$988k
Amnis ImageStreamX MarkII Imaging Flow CytometerS10OD026959 · OD · UNIVERSITY OF UTAH · PI MARVIN, JAMES E · 2020 to 2020
$517k
Regulation of optic stalk development by microgliaR21EY034753 · NEI · UNIVERSITY OF UTAH · PI VETTER, MONICA L · 2023 to 2023
$424k
Microglial contributions to the development of the mammalian optic stalkF31EY035163 · NEI · UNIVERSITY OF UTAH · PI GHENA, NATHANIEL · 2023 to 2023
$37k
NCI NIH HHS P30 CA042014NEI NIH HHS F31 EY035163NEI NIH HHS R01 EY030307NEI NIH HHS R21 EY034753NEI NIH HHS T32 EY024234NIH HHS S10 OD026959NINDS NIH HHS T32 NS115664
6 · The paper itself

Abstract

Microglia, the parenchymal macrophage of the central nervous system serve crucial remodeling functions throughout development. Microglia are transcriptionally heterogenous, suggesting that distinct microglial states confer discrete roles. Currently, little is known about how dynamic these states are, the cues that promote them, or how they impact microglial function. In the developing retina, we previously found a significant proportion of microglia express CD11c (Integrin αX, complement receptor 4,

Identifiers

PMID38979153
PMCPMC11230207

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.