ArticleClinical kidney journal2024
The impact of dialysate flow rate on haemodialysis adequacy: a systematic review and meta-analysis.
Article in Clinical kidney journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Effect of intra-dialytic pedaling exercise on dialysis adequacy: A randomized controlled trial.PloS one · 2026Trial
- Real-world effectiveness of central dialysis fluid delivery system (CDDS) in maintenance hemodialysis: a retrospective multicenter study.Renal failure · 2026Article
- A website calculator to benchmark the carbon footprint of haemodialysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Article
- Systematic Review of Kidney Replacement Therapy During Active Cardiopulmonary Resuscitation.Kidney international reports · 2026Article
- Advancing green nephrology: a scoping review of sustainability interventions in kidney care.International urology and nephrology · 2026Article
- The correlation between depression and haemodialysis adequacy in chronic kidney disease patients in South Africa.Health SA = SA Gesondheid · 2026Article
- Exploring the relationship between intravenous iron therapy and troponin T levels in hemodialysis patients: a cross-sectional study.BMC nephrology · 2025Article
- Biocompatibility in hemodialysis: artificial membrane and human blood interactions.BMC nephrology · 2025Review
- Comparison of the Dialysis Adequacy Across Four Types of Dialysis Machines in Hemodialysis Patients.Iranian journal of nursing and midwifery researchArticle
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Authors and funding
9 authors.
Funding
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Abstract
Background: Patients with kidney failure treated with maintenance haemodialysis (HD) require appropriate small molecule clearance. Historically, a component of measuring 'dialysis adequacy' has been quantified using urea kinetic modelling that is dependent on the HD prescription. However, the impact of dialysate flow rate on urea clearance remains poorly described Methods: We searched Embase, MEDLINE and the Cochrane Library from inception until April 2022 for randomized controlled trials and observational trials comparing a higher dialysate flow rate (800 ml/min) and lower dialysate flow rate (300 ml/min) with a standard dialysis flow rate (500 ml/min) in adults (age ≥18 years) treated with maintenance HD (>90 consecutive days). We conducted a random effects meta-analysis to estimate the pooled mean difference in dialysis adequacy as measured by Kt/V or urea reduction ratio (URR). Results: A total of 3118 studies were identified. Of those, nine met eligibility criteria and four were included in the meta-analysis. A higher dialysate flow rate (800 ml/min) increased single-pool Kt/V by 0.08 [95% confidence interval (CI) 0.05-0.10, Conclusion: A higher dialysate flow increased urea-based markers of dialysis adequacy. Additional high-quality research is needed to determine the clinical, economic and environmental impacts of higher dialysate flow rates.
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