Evidence map›Paper›PMID 38978814›Full record

ArticleFrontiers in neurology2024

Potential thresholds of critically increased cardiac-related spinal cord motion in degenerative cervical myelopathy.

Nikolai Pfender, Catherine R Jutzeler, Michèle Hubli, Paulina S Scheuren, Dario Pfyffer, Carl M Zipser, Jan Rosner, Susanne Friedl, Reto Sutter, José M Spirig and 7 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02170155 (MRI-changes in Morphometry and Cerebro Spinale Fluid), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02170155 recruitingnot on this map

MRI-changes in Morphometry and Cerebro Spinale Fluid (CSF) Flow in Spinal Cord Disorders

TypeobservationalSponsorUniversity of ZurichRan2012 to 2026Enrolled350ConditionsSpinal Injury
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nikolai PfenderSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Catherine R JutzelerDepartment of Health Sciences and Technology, ETH, Zurich, Zurich, Switzerland.
Michèle HubliSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Paulina S ScheurenSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Dario PfyfferSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Carl M ZipserSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Jan RosnerSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Susanne FriedlSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Reto SutterDepartment of Radiology, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
José M SpirigUniversity Spine Center Zurich, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Michael BetzUniversity Spine Center Zurich, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Martin SchubertSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Maryam SeifSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Patrick FreundSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Mazda FarshadUniversity Spine Center Zurich, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Armin CurtSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Markus HuppSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: New diagnostic techniques are a substantial research focus in degenerative cervical myelopathy (DCM). This cross-sectional study determined the significance of cardiac-related spinal cord motion and the extent of spinal stenosis as indicators of mechanical strain on the cord. Methods: Eighty-four DCM patients underwent MRI/clinical assessments and were classified as MRI+ [T2-weighted (T2w) hyperintense lesion in MRI] or MRI- (no T2w-hyperintense lesion). Cord motion (displacement assessed by phase-contrast MRI) and spinal stenosis [adapted spinal canal occupation ratio (aSCOR)] were related to neurological (sensory/motor) and neurophysiological readouts [contact heat evoked potentials (CHEPs)] by receiver operating characteristic (ROC) analysis. Results: MRI+ patients ( Discussion: These findings affirm cord motion measurements as a promising additional biomarker to improve the clinical workup and to enable timely surgical treatment particularly in MRI- DCM patients. Clinical trial registration: www.clinicaltrials.gov, NCT02170155.

Indexed as

cervical cordcervical spondylotic myelopathy (CSM)degenerative cervical myelopathy (DCM)phase contrast MRI (PC-MRI)spinal cord motionspinal cord oscillationsspinal stenosis

Identifiers

PMID38978814
PMCPMC11228334

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.