Evidence map›Paper›PMID 38978669›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Beta Burst-Driven Adaptive Deep Brain Stimulation Improves Gait Impairment and Freezing of Gait in Parkinson's Disease.

K B Wilkins, M N Petrucci, E F Lambert, J A Melbourne, A S Gala, P Akella, L Parisi, C Cui, Y M Kehnemouyi, S L Hoffman and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

K B WilkinsDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.ORCID 0000-0001-5907-4029
M N PetrucciDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
E F LambertDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
J A MelbourneDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
A S GalaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
P AkellaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
L ParisiDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
C CuiDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
Y M KehnemouyiDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
S L HoffmanDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
S AdithamDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
C DiepDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
H J DorrisDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
J E ParkerDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
J A HerronDepartment of Neurological Surgery, University of Washington, Seattle, WA, United States.
H M Bronte-StewartDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.ORCID 0000-0002-1839-4541

Funding

Bilateral Closed Loop Deep Brain Stimulation for Freezing of Gait using Neural and Kinematic FeedbackUH3NS107709 · NINDS · STANFORD UNIVERSITY · PI BRONTE-STEWART, HELEN · 2019 to 2023
$6.1M
Accelerating Dissemination of Implantable Neurotechnology for Clinical ResearchU24NS113637 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BORTON, DAVID ALLENSON, DENISON, TIMOTHY · 2020 to 2024
$4.4M
NINDS NIH HHS U24 NS113637NINDS NIH HHS UH3 NS107709
6 · The paper itself

Abstract

Background: Freezing of gait (FOG) is a debilitating symptom of Parkinson's disease (PD) that is often refractory to medication. Pathological prolonged beta bursts within the subthalamic nucleus (STN) are associated with both worse impairment and freezing behavior in PD, which are improved with deep brain stimulation (DBS). The goal of the current study was to investigate the feasibility, safety, and tolerability of beta burst-driven adaptive DBS (aDBS) for FOG in PD. Methods: Seven individuals with PD were implanted with the investigational Summit Results: Beta burst driven aDBS was successfully implemented and deemed safe and tolerable in all seven participants. Gait metrics such as overall percent time freezing and mean peak shank angular velocity improved from OFF to aDBS and showed similar efficacy as cDBS. Similar improvements were also seen for overall clinical motor impairment, including tremor, as well as quantitative metrics of bradykinesia. Conclusion: Beta burst driven adaptive DBS was feasible, safe, and tolerable in individuals with PD with gait impairment and FOG.

Identifiers

PMID38978669
PMCPMC11230310

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.