ArticlemedRxiv : the preprint server for health sciences2024
Variants in Vitamin D-related Genes and Prostate Cancer Risk in Black Men.
Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundThe relationship between vitamin D and prostate cancer has primarily been characterized among White men. However, Black men have higher prostate cancer incidence and mortality rates, chronically low circulating vitamin D levels, and ancestry-specific genetic variants in vitamin D-related genes. Here, we examine six critical genes in the vitamin D pathway and prostate cancer risk in Black men.
methodsWe assessed a total of 69 candidate variants in six genes (
resultsNone of the variants examined were significantly associated with prostate cancer risk among Black men after multiple comparison adjustment. Four variants tested P<0.05 in Black men, including two in
conclusionWe observed suggestive non-significant associations between genetic variants in
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