ArticlemedRxiv : the preprint server for health sciences2024
Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing.
Cyril Pottier, Fahri Küçükali, Matt Baker, Anthony Batzler, Gregory D Jenkins, Marka van Blitterswijk, Cristina T Vicente, Wouter De Coster, Sarah Wynants, Pieter Van de Walle and 108 more
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In one paragraphArticle in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
118 authors.
Cyril Pottier
Matt Baker
Anthony Batzler
Gregory D Jenkins
Marka van Blitterswijk
Cristina T Vicente
Wouter De Coster
Sarah Wynants
Pieter Van de Walle
Owen A Ross
Júlia Faura
Stephen J Haggarty
Jeroen Gj van Rooij
Linn Öijerstedt
Manuela Neumann
Yan Asmann
Shannon K McDonnell
Saurabh Baheti
Keith A Josephs
Jennifer L Whitwell
Kevin F Bieniek
Leah Forsberg
Hilary Heuer
Argentina Lario Lago
Ethan G Geier
Alexis P Oddi
Margaret Flanagan
Qinwen Mao
John R Hodges
John B Kwok
Kimiko Domoto-Reilly
Bret M Evers
David G Munoz
Julia Keith
Lorne Zinman
Ekaterina Rogaeva
EunRan Suh
Tamar Gefen
Changiz Geula
Sandra Weintraub
Janine Diehl-Schmid
Martin R Farlow
Dieter Edbauer
Bryan K Woodruff
Richard J Caselli
Laura L Donker Kaat
Edward D Huey
Simon Mead
Andrew King
Sigrun Roeber
Alissa L Nana
Nilufer Ertekin-Taner
David S Knopman
Ronald C Petersen
Leonard Petrucelli
Ryan J Uitti
Zbigniew K Wszolek
Eliana Marisa Ramos
Lea T Grinberg
Maria Luisa Gorno Tempini
Howard J Rosen
Salvatore Spina
Murray Grossman
John Q Trojanowski
Dirk C Keene
Jin Lee-Way
Johannes Prudlo
Daniel H Geschwind
Robert A Rissman
Bernardino Ghetti
Thomas G Beach
Thomas Arzberger
Jochen Herms
Adam L Boxer
Jean P Vonsattel
Oscar L Lopez
Julia Kofler
Marla Gearing
Jonathan Glass
Jonathan D Rohrer
David J Irwin
Vivianna Van Deerlin
Rudolph Castellani
Marsel M Mesulam
Maria C Tartaglia
Elizabeth C Finger
Claire Troakes
Safa Al-Sarraj
Bruce L Miller
Neill R Graff-Radford
Ian Ra Mackenzie
John C van Swieten
William W Seeley
Kristel Sleegers
Joanna M Biernacka
Funding
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9MUCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOUGLAS R GALASKO · 2019 to 2026
$34.9MNeuropathology CoreP30AG013854 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI VASSAR, ROBERT J · 1996 to 2020
$28.9MResearch Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR · 2021 to 2026
$26.3MResearch Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8MProgressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0MPrimary Progressive Aphasia: Cognition, Anatomy and ProgressionRF1NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2022 to 2022
$4.7MWhole genome sequencing consortium on Frontotemporal dementia with underlying TDP-43 pathologyUH3NS103870 · NINDS · MAYO CLINIC JACKSONVILLE · PI RADEMAKERS, ROSA · 2019 to 2021
$3.7MWhole genome sequencing consortium on Frontotemporal dementia with underlying TDP-43 pathologyUG3NS103870 · NINDS · MAYO CLINIC JACKSONVILLE · PI RADEMAKERS, ROSA · 2017 to 2018
$1.9MTraining program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9MMedical Research Council MC_U123160651Medical Research Council MC_UU_00024/1Medical Research Council MC_UU_00037/1NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG072977NIA NIH HHS P30 AG072979NIDCD NIH HHS K24 DC015544NINDS NIH HHS R01 NS050915NINDS NIH HHS RF1 NS050915NINDS NIH HHS UG3 NS103870NINDS NIH HHS UH3 NS103870
6 · The paper itselfAbstract
Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) is a fatal neurodegenerative disorder with only a limited number of risk loci identified. We report our comprehensive genome-wide association study as part of the International FTLD-TDP Whole-Genome Sequencing Consortium, including 985 cases and 3,153 controls, and meta-analysis with the Dementia-seq cohort, compiled from 26 institutions/brain banks in the United States, Europe and Australia. We confirm
Identifiers
PMID38978643
PMCPMC11230325
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