Evidence map›Paper›PMID 38978630›Full record

ArticleFrontiers in endocrinology2024

The interference of anti-TSH autoantibody on clinical TSH detection.

Mulin Tang, Xue Meng, Jiajia Ni, Xue Liu, Xinhui Wang, Yuchen Li, Yuwei Chai, Chunjia Kou, Li Zhang, Haiqing Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mulin TangKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Xue MengKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Jiajia NiDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
Xue LiuDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Xinhui WangDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Yuchen LiDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Yuwei ChaiDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Chunjia KouDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Li ZhangDepartment of Vascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, Jinan, China.
Haiqing ZhangKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: It is well known that macro-thyroid-stimulating hormone (macro-TSH) could interfere with the detection of TSH. The anti-TSH autoantibody is an essential component of macro-TSH. However, the epidemiological characteristics and the clinical interference of the anti-TSH autoantibody are unclear. Methods: In this study, the radioimmunoprecipitation technique was used to detect the anti-TSH autoantibody. Platforms with different detection mechanisms were applied to measure the TSH in patients with the anti-TSH autoantibody. Polyethylene glycol (PEG) precipitation was used to determine the immunoassay interference. Results: The prevalence of the anti-TSH autoantibody in patients with mild subclinical hypothyroidism (SCH) and autoimmune thyroiditis, but normal thyroid function, was 4.78%. All 10 patients with anti-TSH antibodies had autoimmune diseases, with five of them having significant clinical test interference. Conclusion: The appearance of the anti-TSH antibody is not associated with thyroid autoantibodies. The presence of the anti-TSH autoantibody can interfere with the detection of TSH and can affect clinical diagnosis and treatment.

Indexed as

AutoantibodiesHypothyroidismThyrotropinAdultAgedFemaleHumansImmunoassayMaleMiddle AgedRadioimmunoprecipitation AssayThyroid Function TestsThyroiditis, AutoimmuneAutoantibodiesThyrotropinanti-TSH autoantibody (TSH-Ab)immunoassay interferencemacro-TSH(M-TSH)PEG precipitationradioimmunoprecipitationTSH

Identifiers

PMID38978630
PMCPMC11228155

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.