Evidence map›Paper›PMID 38978591›Full record

ArticleResearch square2024

Structure and function of a ligand-free GPCR-Gαβγ intermediate complex.

Maxine Bi, Xudong Wang, Jinan Wang, Jun Xu, Wenkai Sun, Victor Ayo Adediwura, Yinglong Miao, Yifan Cheng, Libin Ye

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maxine BiDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94143.
Xudong WangDepartment of Molecular Biosciences, University of South Florida, 4202 E Fowler Ave, Tampa, FL USA 33620.ORCID https://orcid.org/0000-0002-9686-2072
Jinan WangDepartment of Pharmacology & Computational Medicinal Program, University of North Carolina at Chapel Hill, 116 Manning Drive, 11004C Mary Ellen Jones Building, Chapel Hill, NC 27599.
Jun XuDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID https://orcid.org/0000-0002-1600-583X
Wenkai SunDepartment of Molecular Biosciences, University of South Florida, 4202 E Fowler Ave, Tampa, FL USA 33620.
Victor Ayo AdediwuraDepartment of Pharmacology & Computational Medicinal Program, University of North Carolina at Chapel Hill, 116 Manning Drive, 11004C Mary Ellen Jones Building, Chapel Hill, NC 27599.
Yinglong MiaoDepartment of Pharmacology & Computational Medicinal Program, University of North Carolina at Chapel Hill, 116 Manning Drive, 11004C Mary Ellen Jones Building, Chapel Hill, NC 27599.
Yifan ChengDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94143.ORCID https://orcid.org/0000-0001-9535-0369
Libin YeDepartment of Molecular Biosciences, University of South Florida, 4202 E Fowler Ave, Tampa, FL USA 33620.ORCID https://orcid.org/0000-0003-0818-2972

Funding

Advancing cryo-EM technology to address difficult biological questionsR35GM140847 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Yifan Cheng · 2021 to 2026
$2.1M
Molecular Biophysics Training GrantT32GM149436 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aashish Manglik · 2023 to 2026
$1.6M
Enhanced Sampling of G-Protein-Coupled Receptor-G Protein InteractionsR01GM132572 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, YINGLONG · 2019 to 2023
$1.5M
The Role of Intermediate Conformations in G Protein-coupled Receptor SignalingR01GM149659 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI Libin Ye · 2023 to 2026
$1.4M
NIGMS NIH HHS R01 GM132572NIGMS NIH HHS R01 GM149659NIGMS NIH HHS R35 GM140847NIGMS NIH HHS T32 GM149436
6 · The paper itself

Abstract

Unraveling the signaling roles of intermediate complexes is pivotal for G protein-coupled receptor (GPCR) drug development. Despite hundreds of GPCR-Gαβγ structures, these snapshots primarily capture the fully activated complex. Consequently, the functions of intermediate GPCR-G protein complexes remain elusive. Guided by a conformational landscape visualized via

Identifiers

PMID38978591
PMCPMC11230506

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.