Evidence map›Paper›PMID 38978581›Full record

ArticleResearch square2024

Huddling substates in mice facilitate dynamic changes in body temperature and are modulated by

Jason G Landen, Morgane Vandendoren, Samantha Killmer, Nicole L Bedford, Adam C Nelson

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jason G LandenDepartment of Zoology and Physiology, University of Wyoming, Laramie, WY, USA.
Morgane VandendorenDepartment of Zoology and Physiology, University of Wyoming, Laramie, WY, USA.
Samantha KillmerDepartment of Zoology and Physiology, University of Wyoming, Laramie, WY, USA.
Nicole L BedfordDepartment of Zoology and Physiology, University of Wyoming, Laramie, WY, USA.
Adam C NelsonDepartment of Zoology and Physiology, University of Wyoming, Laramie, WY, USA.ORCID 0000-0002-7748-6497

Funding

Zebrafish Models of CNS Injury and Locomotor RecoveryP20GM121310 · NIGMS · UNIVERSITY OF WYOMING · PI Brandon L Roberts · 2017 to 2026
$27.2M
NIGMS NIH HHS P20 GM121310
6 · The paper itself

Abstract

Social thermoregulation is a means of maintaining homeostatic body temperature. While adult mice are a model organism for studying both social behavior and energy regulation, the relationship between huddling and core body temperature (Tb) is poorly understood. Here, we develop a behavioral paradigm and computational tools to identify active-huddling and quiescent-huddling as distinct thermal substates. We find that huddling is an effective thermoregulatory strategy in female but not male groups. At 23°C (room temperature), but not 30°C (near thermoneutrality), huddling facilitates large reductions in Tb and Tb-variance. Notably, active-huddling is associated with bidirectional changes in Tb, depending on its proximity to bouts of quiescent-huddling. Further, group-housed animals lacking the synaptic scaffolding gene

Identifiers

PMID38978581
PMCPMC11230468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.