ArticleResearch square2024
Knockdown of microglial iron import gene, DMT1, worsens cognitive function and alters microglial transcriptional landscape in a sex-specific manner in the APP/PS1 model of Alzheimer's disease.
Katrina Volk Robertson, Alec S Rodriguez, Jean-Philippe Cartailler, Shristi Shrestha, Kyle R Schroeder, Arianna M Valenti, Fiona E Harrison, Alyssa H Hasty
Abstract readPreprint
In one paragraphArticle in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Katrina Volk RobertsonVanderbilt University.
Alec S RodriguezVanderbilt University.
Jean-Philippe CartaillerVanderbilt University.
Shristi ShresthaVanderbilt University.
Kyle R SchroederVanderbilt University.
Arianna M ValentiVanderbilt University.
Fiona E HarrisonVanderbilt University Medical Center.
Alyssa H HastyVanderbilt University.
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6MMULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9MOverall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3MVANTAGE:Consolidation to create the Vanderbilt Technologies for Advanced GenomicsG20RR030956 · NCRR · VANDERBILT UNIVERSITY · PI PIETENPOL, JENNIFER A · 2010 to 2010
$8.7MVanderbilt Alzheimer's Disease Research CenterP20AG068082 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NEWHOUSE, PAUL A. · 2020 to 2023
$5.6MVanderbilt Interdisciplinary Training Program in Alzheimer's DiseaseT32AG058524 · NIA · VANDERBILT UNIVERSITY · PI ANGELA L. JEFFERSON · 2018 to 2026
$3.5MAdipose Macrophage Iron HandlingR01DK121520 · NIDDK · VANDERBILT UNIVERSITY · PI WINN, NATHAN C · 2019 to 2023
$2.8MManganese exposure susceptibility as a modifier of excitotoxicity in Alzheimer's DiseaseR01ES031401 · NIEHS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BOWMAN, AARON B, HARRISON, FIONA EDITH · 2020 to 2024
$2.7MTargeting microglial cell iron-handling in Alzheimer’s DiseaseF31AG081025 · NIA · VANDERBILT UNIVERSITY · PI VOLK, KATRINA · 2023 to 2023
$31kBLRD VA IK6 BX005649NCI NIH HHS P30 CA068485NCRR NIH HHS G20 RR030956NCRR NIH HHS UL1 RR024975NEI NIH HHS P30 EY008126NIA NIH HHS F31 AG081025NIA NIH HHS P20 AG068082NIA NIH HHS T32 AG058524NICHD NIH HHS P50 HD103537NIDDK NIH HHS P30 DK020593NIDDK NIH HHS R01 DK121520NIDDK NIH HHS T32 DK007563NIEHS NIH HHS R01 ES031401
6 · The paper itselfAbstract
Background: Microglial cell iron load and inflammatory activation are significant hallmarks of late-stage Alzheimer's disease (AD). Methods: Results: DMT1 inhibition Conclusions: This work suggests a sex-specific role for microglial iron import gene
Indexed as
Alzheimer’s diseaseAPP/PS1behaviorDMT1inflammationironmicroglianeuroinflammationsex differencesSlc11a2
Identifiers
PMID38978579
PMCPMC11230470
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