ArticleResearch square2024
Brain clocks capture diversity and disparity in aging and dementia.
Abstract readPreprint
In one paragraph
Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Updated by
Authors and funding
75 authors.
Sebastian MoguilnerLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Sandra BaezUniversidad de los Andes, Bogota, Colombia.
Hernan HernandezLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.ORCID 0000-0002-0597-6059
Joaquín MigeotLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Agustina LegazLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Raul Gonzalez-GomezLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Francesca R FarinaGlobal Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.
Pavel PradoLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.ORCID 0000-0002-1324-6400
Jhosmary CuadrosLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Enzo TagliazucchiLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Florencia AltschulerCognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.
Marcelo Adrián MaitoLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
María E GodoyLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Josephine CruzatLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Pedro A Valdes-SosaThe Clinical Hospital of Chengdu Brain Sciences, University of Electronic Sciences.ORCID 0000-0001-5485-2661
Francisco LoperaGrupo de Neurociencias de Antioquia (GNA) University of Antioquia, Medellín, Colombia.
John Fredy Ochoa-GómezGrupo de Neurociencias de Antioquia (GNA) University of Antioquia, Medellín, Colombia.
Alfredis Gonzalez HernandezDepartment of Psychology, Master program of Clinical Neuropsychology, Universidad Surcolombiana Neiva, Neiva - Huila, Colombia.
Jasmin Bonilla-SantosDepartment of Psychology, Universidad Cooperativa de Colombia.
Rodrigo A Gonzalez-MontealegreNeurocognition and Psychophysiology Laboratory, Universidad Surcolombiana, Neiva - Huila, Colombia.ORCID 0000-0003-1805-5766
Renato AnghinahReference Center of Behavioural Disturbances and Dementia, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Luís E d'Almeida ManfrinatiReference Center of Behavioural Disturbances and Dementia, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Sol FittipaldiLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Vicente MedelLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Daniela OlivaresLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Görsev G YenerFaculty of Medicine, Izmir University of Economics, 35330, Izmir, Turkey.ORCID 0000-0002-7756-4387
Javier EscuderoSchool of Engineering, Institute for Imaging, Data and Communications, University of Edinburgh, Scotland, UK.
Claudio BabiloniDepartment of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, Rome, Italy.
Robert WhelanGlobal Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.
Bahar GüntekinDepartment of Neurosciences, Health Sciences Institute, Istanbul Medipol University, İstanbul, Turkey.
Harun YırıkoğullarıDepartment of Neurosciences, Health Sciences Institute, Istanbul Medipol University, İstanbul, Turkey.
Hernando Santamaria-GarciaPontificia Universidad Javeriana (PhD Program in Neuroscience) Bogotá, San Ignacio, Colombia.
Alberto Fernández LucasDepartamento de Medicina Legal, Psiquiatría y Patología, Facultad de Medicina, Universidad Complutense de Madrid.
David HuepeCenter for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibáñez.
Gaetano Di CaterinaDepartment of Electronic and Electrical Engineering, University of Strathclyde, Glasgow, UK.
Marcio Soto-AñariUniversidad Católica San Pablo, Arequipa, Peru.ORCID 0000-0002-9121-3284
Agustina BirbaLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Agustin Sainz-BallesterosLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Carlos Coronel-OliverosLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Amanuel YigezuTrinity College Dublin, The University of Dublin, Dublin, Ireland.ORCID 0000-0003-2792-2163
Eduar HerreraDepartamento de Estudios Psicológicos, Universidad ICESI, Cali, Colombia.
Daniel AbasoloCentre for Biomedical Engineering, School of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford GU2 7XH, UK.ORCID 0000-0002-4268-2885
Kerry KilbornSchool of Psychology, University of Glasgow, Glasgow, Scotland.
Nicolás RubidoInstitute for Complex Systems and Mathematical Biology, University of Aberdeen, Aberdeen, AB24 3UE, UK.ORCID 0000-0002-0616-2479
Ruaridh A ClarkCentre for Signal and Image Processing, Department of Electronic and Electrical Engineering, University of Strathclyde, UK.
Ruben HerzogLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.ORCID 0000-0002-3498-5819
Deniz YerlikayaDepartment of Neurosciences, Health Sciences Institute, Dokuz Eylül University, Izmir, Turkey.
Kun HuHarvard Medical School, Boston, USA.
Mario A ParraDepartment of Psychological Sciences and Health, University of Strathclyde, Glasgow, United Kingdom; Researcher associate of BrainLat, Universidad Adolfo Ibáñez, Santiago, Chile.
Pablo ReyesPontificia Universidad Javeriana (PhD Program in Neuroscience) Bogotá, San Ignacio, Colombia.
Adolfo M GarcíaCognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.
Diana L MatallanaPontificia Universidad Javeriana (PhD Program in Neuroscience) Bogotá, San Ignacio, Colombia.
José Alberto Avila-FunesDepartment of Geriatrics. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico City, Mexico.ORCID 0000-0003-0033-5508
Andrea SlachevskyMemory and Neuropsychiatric Center (CMYN), Neurology Department, Hospital del Salvador & Faculty of Medicine, University of Chile, Santiago, Chile.
María I BehrensNeurology and Psychiatry Department, Clínica Alemana-Universidad Desarrollo, Santiago, Chile.
Nilton CustodioServicio de Neurología, Instituto Peruano de Neurociencias, Lima, Perú.
Juan F CardonaFacultad de Psicología, Universidad del Valle, Santiago de Cali, Colombia.
Pablo BarttfeldCognitive Science Group. Instituto de Investigaciones Psicológicas (IIPsi), CONICET UNC, Facultad de Psicología, Universidad Nacional de Córdoba, Boulevard de la Reforma esquina Enfermera Gordillo, CP 5000. Córdoba, Argentina.
Ignacio L BruscoCentro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina.
Martín A BrunoInstituto de Ciencias Biomédicas (ICBM) Facultad de Ciencias Médicas, Universidad Catoóica de Cuyo, San Juan, Argentina.
Ana L Sosa OrtizInstituto Nacional de Neurologia y Neurocirugia MVS, Universidad Nacional Autonoma de Mexico, Mexico, Mexico.
Stefanie D Pina-EscuderoGlobal Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.
Leonel T TakadaCognitive and Behavioral Neurology Unit, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil.ORCID 0000-0002-0121-9253
Elisa ResendeUniversidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Katherine L PossinGlobal Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.
Maira Okada de OliveiraGlobal Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.
Alejandro Lopez-ValdesGlobal Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.
Brain LawlorGlobal Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.
Ian H RobertsonGlobal Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.
Kenneth S KosikThe University of Chicago, Division of the Biological Sciences, 5841 S Maryland Avenue Chicago, IL 60637, USA.ORCID 0000-0003-3224-5179
Claudia Duran-AniotzLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Victor ValcourGlobal Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.
Jennifer S YokoyamaGlobal Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.ORCID 0000-0001-7274-2634
Bruce L MillerGlobal Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.
Agustin IbanezLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.ORCID 0000-0001-6758-5101
Funding
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MAn automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2MUS-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1MCircadian Disturbance and Dementia in Latin AmericaR01AG083799 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Kun Hu, Agustin M. Ibanez · 2023 to 2026
$3.0MNIA NIH HHS P01 AG019724NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG075775NIA NIH HHS R01 AG083799NIDA NIH HHS 75N95022C00031
Abstract
Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding brain health and disease. However, the impact of multimodal diversity (geographical, socioeconomic, sociodemographic, sex, neurodegeneration) on the brain age gap (BAG) is unknown. Here, we analyzed datasets from 5,306 participants across 15 countries (7 Latin American countries -LAC, 8 non-LAC). Based on higher-order interactions in brain signals, we developed a BAG deep learning architecture for functional magnetic resonance imaging (fMRI=2,953) and electroencephalography (EEG=2,353). The datasets comprised healthy controls, and individuals with mild cognitive impairment, Alzheimer's disease, and behavioral variant frontotemporal dementia. LAC models evidenced older brain ages (fMRI: MDE=5.60, RMSE=11.91; EEG: MDE=5.34, RMSE=9.82) compared to non-LAC, associated with frontoposterior networks. Structural socioeconomic inequality and other disparity-related factors (pollution, health disparities) were influential predictors of increased brain age gaps, especially in LAC (R
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.