Evidence map›Paper›PMID 38978568›Full record

ArticleResearch square2024

Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-Dubé syndrome through transcriptiomic and proteomic analysis.

Andrew Tee, Rachel-Ann Jones, Elaine A Dunlop, Jesse Champion, Peter Doubleday, Tijs Claessens, Zahra Jalali, Sara Seifan, Iain Perry, Peter Giles and 5 more

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Andrew TeeCardiff University.ORCID 0000-0002-5577-4631
Rachel-Ann JonesCardiff University.
Elaine A DunlopCardiff University.ORCID 0000-0002-9209-7561
Jesse ChampionCardiff University.
Peter DoubledayUniversity of Cardiff.
Tijs ClaessensUniversity of Cardiff.
Zahra JalaliUniversity of Cardiff.
Sara SeifanUniversity of Cardiff.
Iain PerryMcGill University.
Peter GilesMcGill University.
Oliver HarrisonMcGill University.
Barry CoullMcGill University.
Arjan HouwelingMcGill University.
Arnim PauseMcGill University.
Bryan Ballif

Funding

Vermont INBRE Administrative Supplement 2024 AWD 118P20GM103449 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI CHRISTOPHER S FRANCKLYN · 2012 to 2026
$58.4M
NIGMS NIH HHS P20 GM103449
6 · The paper itself

Abstract

Birt-Hogg-Dubé (BHD) syndrome patients are uniquely susceptible to all renal tumour subtypes. The underlying mechanism of carcinogenesis is unclear. To study cancer development in BHD, we used human proximal kidney (HK2) cells and found that long-term folliculin

Identifiers

PMID38978568
PMCPMC11230511

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.