Evidence map›Paper›PMID 38978508›Full record

ReviewAnatomy & cell biology2024

Transplantation of human umbilical cord mesenchymal stem cells optimized with IFN-γ is a potential procedure for modification of motor impairment in multiple sclerosis cases: a preclinical systematic review and meta-analysis study.

Mohamad Mahdi Esmaeili Araghi, Amir Abdolmaleki, Hadi Esmaeili Gouvarchin Ghaleh, Bahman Jalali Kondori, Akbar Ghorbani Alvanegh, Mehrdad Moosazadeh Moghaddam, Seyed Javad Hosseini Nejad Anbaran

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Anatomy & cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohamad Mahdi Esmaeili AraghiStudents Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0009-0008-5645-4374
Amir AbdolmalekiDepartment of Operating Room, Nahavand School of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.ORCID https://orcid.org/0000-0001-9541-8829
Hadi Esmaeili Gouvarchin GhalehApplied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0001-8562-2295
Bahman Jalali KondoriBaqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Baqiyatallah University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-6134-9965
Akbar Ghorbani AlvaneghHuman Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0001-8958-4812
Mehrdad Moosazadeh MoghaddamApplied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-4645-8661
Seyed Javad Hosseini Nejad AnbaranDepartment of Neurology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0003-1770-2968

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cells transplantation (SCT) is known as a newfound strategy for multiple sclerosis (MS) treatment. Human umbilical cord mesenchymal stem cells (hUCMSCs) contain various regenerative features. Experimental autoimmune encephalomyelitis (EAE) is a laboratory model of MS. This meta-analysis study was conducted to assess the overall therapeutic effects of hUCMSCs on reduction of clinical score (CS) and restoration of active movement in EAE-induced animals. For comprehensive searching (in various English and Persian databases until May 1, 2024), the main keywords of "Experimental Autoimmune Encephalomyelitis", "Multiple Sclerosis", "Human", "Umbilical Cord", "Mesenchymal", and "Stem Cell" were hired. Collected data were transferred to the citation manager software (EndNote x8) and duplicate papers were merged. Primary and secondary screenings were applied (according to the inclusion and exclusion criteria) and eligible studies were prepared for data collection. CS of two phases of peak and recovery of EAE were extracted as the difference in means and various analyses including heterogeneity, publication bias, funnel plot, and sensitivity index were reported. Meta-analysis was applied by CMA software (v.2),

Indexed as

Cell therapyMesenchymal stem cellMultiple sclerosisTransplantationUmbilical cord

Identifiers

PMID38978508
PMCPMC11424570

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.