Evidence map›Paper›PMID 38978507›Full record

ArticleActa biochimica et biophysica Sinica2024

Role of Emerin in regulating fibroblast differentiation and migration at the substrate of stiffness coupled topology.

Tiantian Yang, Li Wang, Haiyang Ma, Kailun Li, Yajing Wang, Wenjie Tang, Zichen Wang, Meiwen An, Xiang Gao, Ludan Xu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tiantian YangCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Li WangCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Haiyang MaCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Kailun LiTrauma Center, Trauma Orthopaedics, ZhouKou Orthopaedic Hospital, Zhoukou 466000, China.
Yajing WangCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Wenjie TangCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Zichen WangCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Meiwen AnCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Xiang GaoCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Ludan XuCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Yunyun GuoCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Jiqiang GuoCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Yong LiuDermatology Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan 030032, China.
Hugen WangOrthopaedics department, the First People's Hospital of Jinzhong, Jinzhong 030600, China.
Yang LiuCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Quanyou ZhangCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In hypertrophic scars, the differentiation and migration of fibroblasts are influenced by the extracellular matrix microenvironment, which includes factors such as stiffness, restraint, and tensile force. These mechanical stresses incite alterations in cell behavior, accompanied by cytoskeletal protein reorganization. However, the role of nucleo-skeletal proteins in this context remains underexplored. In this study, we use a polyacrylamide hydrogel (PAA) to simulate the mechanical stress experienced by cells in scar tissue and investigate the impact of Emerin on cell behavior. We utilize atomic force microscopy (AFM) and RNA interference technology to analyze cell differentiation, migration, and stiffness. Our findings reveal that rigid substrates and cellular restriction elevate Emerin expression and diminish differentiation. Conversely, reducing Emerin expression leads to attenuated cell differentiation, where stiffness and constraining factors exert no notable influence. Furthermore, a softening of cells and an enhanced migration rate are also markedly observed. These observations indicate that variations in nuclear skeletal proteins, prompted by diverse matrix microenvironments, play a pivotal role in the pathogenesis of hypertrophic scars (HSs). This research offers novel insights and a reference point for understanding scar fibrosis formation mechanisms and preventing fibrosis.

Indexed as

Cell DifferentiationCell MovementFibroblastsMembrane ProteinsMicroscopy, Atomic ForceNuclear ProteinsAcrylic ResinsCicatrix, HypertrophicExtracellular MatrixHumansStress, MechanicalAcrylic ResinsemerinMembrane ProteinsNuclear Proteinscell differentiationcell migrationhyperplastic scarmatrix microenvironmentnuclear skeleton protein

Identifiers

PMID38978507
PMCPMC11532208

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.