Evidence map›Paper›PMID 38978088›Full record

ArticleGenome biology2024

Panpipes: a pipeline for multiomic single-cell and spatial transcriptomic data analysis.

Fabiola Curion, Charlotte Rich-Griffin, Devika Agarwal, Sarah Ouologuem, Kevin Rue-Albrecht, Lilly May, Giulia E L Garcia, Lukas Heumos, Tom Thomas, Wojciech Lason and 3 more

Abstract read
In one paragraph

Article in Genome biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Integrating Spatial Proteogenomics in Cancer Research.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fabiola Curion *Department of Computational Health, Institute of Computational Biology, Helmholtz Munich, Germany.
Charlotte Rich-Griffin *Nuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK.
Devika AgarwalNuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK.
Sarah OuologuemDepartment of Computational Health, Institute of Computational Biology, Helmholtz Munich, Germany.
Kevin Rue-AlbrechtMRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Lilly MayDepartment of Computational Health, Institute of Computational Biology, Helmholtz Munich, Germany.
Giulia E L GarciaNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Lukas HeumosDepartment of Computational Health, Institute of Computational Biology, Helmholtz Munich, Germany.
Tom ThomasNuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK.
Wojciech LasonNuffield Department of Medicine, Respiratory Medicine Unit, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, UK.
David SimsMRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Fabian J TheisDepartment of Computational Health, Institute of Computational Biology, Helmholtz Munich, Germany. fabian.theis@helmholtz-muenchen.de.
Calliope A DendrouNuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK. calliope.dendrou@kennedy.ox.ac.uk.ORCID 0000-0003-1179-4021

Funding

Deutsche Forschungsgemeinschaft SFB- TRR 338/1 2021 -452881907Medical Research Council MR/R015708/1Medical Research Council MR/T030410/1NIHR Oxford Biomedical Research Centre BRCRCF10-04Rosetrees Trust R35579/AA002/M85-F2Wellcome TrustWellcome Trust 204290/Z/16/Z
6 · The paper itself

Abstract

Single-cell multiomic analysis of the epigenome, transcriptome, and proteome allows for comprehensive characterization of the molecular circuitry that underpins cell identity and state. However, the holistic interpretation of such datasets presents a challenge given a paucity of approaches for systematic, joint evaluation of different modalities. Here, we present Panpipes, a set of computational workflows designed to automate multimodal single-cell and spatial transcriptomic analyses by incorporating widely-used Python-based tools to perform quality control, preprocessing, integration, clustering, and reference mapping at scale. Panpipes allows reliable and customizable analysis and evaluation of individual and integrated modalities, thereby empowering decision-making before downstream investigations.

Indexed as

Single-Cell AnalysisSoftwareTranscriptomeGene Expression ProfilingHumansWorkflow

Identifiers

PMID38978088
PMCPMC11229213

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.