Evidence map›Paper›PMID 38978068›Full record

Observational studyRespiratory research2024

Associations of early changes in lung ultrasound aeration scores and mortality in invasively ventilated patients: a post hoc analysis.

Jante S Sinnige, Daan F L Filippini, Laura A Hagens, Nanon F L Heijnen, Ronny M Schnabel, Marcus J Schultz, Dennis C J J Bergmans, Lieuwe D J Bos, Marry R Smit

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04482621 (Decitabine for COVID-19 Pneumonia-ARDS Treatment), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04482621 phase2suspendednot on this map

Decitabine for COVID-19 Pneumonia-ARDS Treatment: DART Trial

TypeinterventionalSponsorJohns Hopkins UniversityRan2020 to 2026Enrolled33ConditionsCOVID-19ArmsDecitabine, Placebo Saline
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Advances in bedside imaging: lung ultrasound.Intensive care medicine experimental · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jante S SinnigeDepartment of Intensive Care, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, the Netherlands. j.s.sinnige@amsterdamumc.nl.
Daan F L FilippiniDepartment of Intensive Care, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, the Netherlands.
Laura A HagensDepartment of Intensive Care, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, the Netherlands.
Nanon F L HeijnenDepartment of Intensive Care, Maastricht UMC+, Maastricht University, Maastricht, 6229 HX, The Netherlands.
Ronny M SchnabelDepartment of Intensive Care, Maastricht UMC+, Maastricht University, Maastricht, 6229 HX, The Netherlands.
Marcus J SchultzDepartment of Intensive Care, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, the Netherlands.
Dennis C J J BergmansDepartment of Intensive Care, Maastricht UMC+, Maastricht University, Maastricht, 6229 HX, The Netherlands.
Lieuwe D J BosDepartment of Intensive Care, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, the Netherlands.
Marry R SmitDepartment of Intensive Care, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLung ultrasound (LUS) in an emerging technique used in the intensive care unit (ICU). The derivative LUS aeration score has been shown to have associations with mortality in invasively ventilated patients. This study assessed the predictive value of baseline and early changes in LUS aeration scores in critically ill invasively ventilated patients with and without ARDS (Acute Respiratory Distress Syndrome) on 30- and 90-day mortality.

methodsThis is a post hoc analysis of a multicenter prospective observational cohort study, which included patients admitted to the ICU with an expected duration of ventilation for at least 24 h. We restricted participation to patients who underwent a 12-region LUS exam at baseline and had the primary endpoint (30-day mortality) available. Logistic regression was used to analyze the primary and secondary endpoints. The analysis was performed for the complete patient cohort and for predefined subgroups (ARDS and no ARDS).

resultsA total of 442 patients were included, of whom 245 had a second LUS exam. The baseline LUS aeration score was not associated with mortality (1.02 (95% CI: 0.99 - 1.06), p = 0.143). This finding was not different in patients with and in patients without ARDS. Early deterioration of the LUS score was associated with mortality (2.09 (95% CI: 1.01 - 4.3), p = 0.046) in patients without ARDS, but not in patients with ARDS or in the complete patient cohort.

conclusionIn this cohort of critically ill invasively ventilated patients, the baseline LUS aeration score was not associated with 30- and 90-day mortality. An early change in the LUS aeration score was associated with mortality, but only in patients without ARDS.

trial registrationClinicalTrials.gov, ID NCT04482621.

Indexed as

LungRespiration, ArtificialRespiratory Distress SyndromeUltrasonographyAgedCohort StudiesCritical IllnessFemaleHumansIntensive Care UnitsMaleMiddle AgedProspective StudiesTime FactorsIntensive Care medicineLongitudinal researchLung ultrasoundMortality

Identifiers

PMID38978068
PMCPMC11232207

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.