ArticleBMC psychiatry2024
Gut microbiome and major depressive disorder: insights from two-sample Mendelian randomization.
Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- Correlation Between Gut Microbiota and Plasma Metabolites in a Mouse Model for Post-Traumatic Stress Disorder.Metabolites · 2026Article
- Gut Microbiota Dysbiosis in Depression: Pathological Correlations, Molecular Pathways, and Therapeutic Interventions.International journal of molecular sciences · 2026Review
- Developmental lead (pb) exposure induces anxiety and depression-like behaviorsCurrent research in toxicology · 2026Article
- Microbiome driven modulation of neurotransmitters: implications for neurotransmission and mood disorders.Frontiers in microbiology · 2026Review
- Integrative evidence for causal links between gut microbiota and Schizophrenia: A Mendelian randomization and 16S rRNA study.Brain, behavior, & immunity - health · 2025Article
- Identifying Druggable Inflammatory Proteins Causally Contributing to Parkinson's Disease.Brain and behavior · 2025Article
- Gut Microbiota and Autism Spectrum Disorders: Neurodevelopmental, Behavioral, and Gastrointestinal Interactions.Nutrients · 2025Article
- Multi-omics analyses of the gut microbiome, fecal metabolome, and multimodal brain MRI reveal the role ofPsychological medicine · 2025Article
- Preliminary Insights Into the Relationship Between the Gut Microbiome and Host Genome in Posttraumatic Stress Disorder.Genes, brain, and behavior · 2025Article
- Article
- Exploring causal associations between plasma metabolites and attention-deficit/hyperactivity disorder.BMC psychiatry · 2025Article
- Gut microbiome links obesity to type 2 diabetes: insights from Mendelian randomization.BMC microbiology · 2025Article
- Liqi Yangyin formula ameliorates CUMS-induced depression and comorbid constipation via ACE/FFAR2 modulation of the microbiota-gut-brain axis.Frontiers in cellular and infection microbiology · 2025Article
- Investigating bidirectional causal relationships between gut microbiota and insomnia.General psychiatry · 2025Article
- Multiple pathways through which the gut microbiota regulates neuronal mitochondria constitute another possible direction for depression.Frontiers in microbiology · 2025Review
- The Microbiota-Gut-Brain Axis in Depression: Mechanisms, Microbiota-Targeted Interventions, and Translational Challenges.International journal of microbiology · 2025Review
- Gut microbiome and schizophrenia: insights from two-sample Mendelian randomization.Schizophrenia (Heidelberg, Germany) · 2024Article
- The Intersection of Ultra-Processed Foods, Neuropsychiatric Disorders, and Neurolaw: Implications for Criminal Justice.NeuroSci · 2024Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExisting evidence suggests that alterations in the gut microbiome are closely associated with major depressive disorder (MDD). We aimed to reveal the causal relationships between MDD and various microbial taxa in the gut.
methodsWe used the two-sample Mendelian randomization (TSMR) to explore the bidirectional causal effects between gut microbiota and MDD. The genome-wide association studies summary results of gut microbiota were obtained from two large consortia, the MibioGen consortium and the Dutch Microbiome Project, which we analyzed separately.
resultsOur TSMR analysis identified 10 gut bacterial taxa that were protective against MDD, including phylum Actinobacteria, order Clostridiales, and family Bifidobacteriaceae (OR: 0.96 ∼ 0.98). Ten taxa were associated with an increased risk of MDD, including phyla Firmicutes and Proteobacteria, class Actinobacteria, and genus Alistipes (OR: 1.01 ∼ 1.09). On the other hand, MDD may decrease the abundance of 12 taxa, including phyla Actinobacteria and Firmicutes, families Bifidobacteriaceae and Defluviitaleaceae (OR: 0.63 ∼ 0.88). MDD may increase the abundance of 8 taxa, including phylum Bacteroidetes, genera Parabacteroides, and Bacteroides (OR: 1.12 ∼ 1.43).
conclusionsOur study supports that there are mutual causal relationships between certain gut microbiota and the development of MDD suggesting that gut microbiota may be targeted in the treatment of MDD.
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