ArticleThe journal of headache and pain2024
White matter and cortical gray matter microstructural abnormalities in new daily persistent headache: a NODDI study.
Article in The journal of headache and pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bibliometric analysis of neurite orientation dispersion and density imaging: research patterns, evolution, and frontier.Frontiers in neuroscience · 2026Pooled it
- Pediatric New Daily Persistent Headache: Integrating Novel Research Methods to Support and Delineate Evolving Clinical Phenotypes.Children (Basel, Switzerland) · 2026Article
- Fixel‑based analysis reveals distributed white matter alterations associated with pain severity in trigeminal neuralgia.The journal of headache and pain · 2026Article
- Methodological Evolution of Diffusion MRI in Chronic Pain: A Narrative Review.Journal of pain research · 2026Review
- Glymphatic system bridges peripheral and central nervous system changes in classic trigeminal neuralgia.Brain communications · 2026Article
- Diffusion tensor imaging in chronic tension-type headache.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Neurite orientation dispersion and density imaging in stroke: current applications, limitations, and future directions.Frontiers in human neuroscience · 2026Review
- Hallmarks of primary headache: part 4 - rare headache syndromes.The journal of headache and pain · 2025Review
- Article
- Mapping global research landscape and trends in magnetic resonance imaging applications for primary trigeminal neuralgia: a bibliometric analysis.Neurosurgical review · 2025Review
- White matter and cortical gray matter microstructural alterations in migraine: a NODDI and DTI analysis.The journal of headache and pain · 2025Article
- Altered white matter microstructural integrity in patients with postherpetic neuralgia: a combined DTI and DTI-NODDI study.Frontiers in neuroscience · 2025Article
- White matter structural changes in the visual pathway of thyroid-associated ophthalmopathy patients: a free water and multi-shell diffusion imaging study.Frontiers in neurology · 2025Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundNew daily persistent headache (NDPH) is a rare primary headache with unclear pathogenesis. Neuroimaging studies of NDPH are limited, and controversy still exists. Diffusion tensor imaging (DTI) is commonly used to study the white matter. However, lacking specificity, the potential pathological mechanisms of white matter microstructural changes remain poorly understood. In addition, the intricacy of gray matter structures impedes the application of the DTI model. Here, we applied an advanced diffusion model of neurite orientation dispersion and density imaging (NODDI) to study the white matter and cortical gray matter microstructure in patients with NDPH.
methodsThis study assessed brain microstructure, including 27 patients with NDPH, and matched 28 healthy controls (HCs) by NODDI. The differences between the two groups were assessed by tract-based spatial statistics (TBSS) and surface-based analysis (SBA), focusing on the NODDI metrics (neurite density index (NDI), orientation dispersion index (ODI), and isotropic volume fraction (ISOVF)). Furthermore, we performed Pearson's correlation analysis between the NODDI indicators and clinical characteristics.
resultsCompared to HCs, patients with NDPH had a reduction of density and complexity in several fiber tracts. For robust results, the fiber tracts were defined as comprising more than 100 voxels, including bilateral inferior fronto-occipital fasciculus (IFOF), left superior longitudinal fasciculus (SLF) and inferior longitudinal fasciculus (ILF), as well as right corticospinal tract (CST). Moreover, the reduction of neurite density was uncovered in the left superior and middle frontal cortex, left precentral cortex, and right lateral orbitofrontal cortex and insula. There was no correlation between the NODDI metrics of these brain regions and clinical variables or scales of relevance after the Bonferroni correction.
conclusionsOur research indicated that neurite loss was detected in both white matter and cortical gray matter of patients with NDPH.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.