Evidence map›Paper›PMID 38977898›Full record

ArticleEuropean heart journal. Cardiovascular pharmacotherapy2024

The dual endothelin-1 antagonist aprocitentan alleviates mitochondrial oxidative stress in human cardiac fibroblasts.

Fahimeh Varzideh, Stanislovas S Jankauskas, Urja Jain, Lauren Soderquist, Esther Densu Agyapong, Urna Kansakar, Gaetano Santulli

Erratum issuedAbstract readLetter
In one paragraph

Article in European heart journal. Cardiovascular pharmacotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Fahimeh VarzidehD epartment of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, New York City, NY, USA.
Stanislovas S JankauskasD epartment of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, New York City, NY, USA.
Urja JainD epartment of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, New York City, NY, USA.
Lauren SoderquistD epartment of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, New York City, NY, USA.
Esther Densu AgyapongD epartment of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, New York City, NY, USA.
Urna KansakarD epartment of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, New York City, NY, USA.
Gaetano SantulliD epartment of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, New York City, NY, USA.ORCID 0000-0001-7231-375X

Funding

REGULATION OF THE INSULIN RECEPTOR KINASER01DK033823 · NIDDK · UNIVERSITY OF IOWA · PI KURLAND, IRWIN JACK, PESSIN, JEFFREY E. · 1986 to 2022
$6.7M
Functional role of IP3 receptors in the regulation of cardiac myofibroblastsR01HL146691 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SANTULLI, GAETANO · 2019 to 2023
$2.1M
Mechanisms of cardiovascular diseaseT32HL144456 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Carlos Jose Rodriguez, Nicholas E Sibinga · 2019 to 2026
$1.9M
Beta Cell Intracellular Calcium and DiabetesR01DK123259 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SANTULLI, GAETANO · 2020 to 2023
$1.7M
Purposeful Outreach for Diversity and Inclusion of Underrepresented in Medicine (PODIUM) Physician-ScientistsT32HL172255 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Carmen R. Isasi, Marina Reznik · 2024 to 2026
$936k
American Heart Association 24IPA1268813NHLBI NIH HHS R01 HL146691NHLBI NIH HHS R01-HL146691NHLBI NIH HHS T32 HL144456NHLBI NIH HHS T32 HL172255NIDDK NIH HHS R01 DK033823NIDDK NIH HHS R01-DK033823NIDDK NIH HHS R01 DK123259NIH HHS
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

FibroblastsOxidative StressCells, CulturedEndothelin-1Endothelin A Receptor AntagonistsEndothelin Receptor AntagonistsHumansMitochondria, HeartEndothelin-1Endothelin A Receptor AntagonistsEndothelin Receptor Antagonists

Identifiers

PMID38977898
PMCPMC11450266

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.