Evidence map›Paper›PMID 38977826›Full record

ArticleScientific reports2024

The dynamic expression of YAP is essential for the development of male germ cells derived from human embryonic stem cells.

Sujittra Khampang, Chanchao Lorthongpanich, Chuti Laowtammathron, Phatchanat Klaihmon, Sukanya Meesa, Wichuda Suksomboon, Nittaya Jiamvoraphong, Pakpoom Kheolamai, Sudjit Luanpitpong, Charles A Easley and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sujittra KhampangSiriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Chanchao LorthongpanichSiriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand. chanchao.lor@mahidol.ac.th.
Chuti LaowtammathronSiriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Phatchanat KlaihmonSiriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Sukanya MeesaDivision of Medical Genetics, Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Wichuda SuksomboonDivision of Medical Genetics, Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Nittaya JiamvoraphongSiriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Pakpoom KheolamaiCenter of Excellence in Stem Cell Research and Innovation, Faculty of Medicine, Thammasat University, Pathum Thani, 12121, Thailand.
Sudjit LuanpitpongSiriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Charles A EasleyDivision of Neuropharmacology and Neurologic Diseases, Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Eisa MahyariDivision of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Portland, OR, 97006, USA.
Surapol IssaragrisilSiriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.

Funding

Mahidol University Postdoctoral Fellow awardNational Research Council of Thailand N41A640154
6 · The paper itself

Abstract

YAP plays a vital role in controlling growth and differentiation in various cell lineages. Although the expression of YAP in mice testicular and spermatogenic cells suggests its role in mammalian spermatogenesis, the role of YAP in the development of human male germ cells has not yet been determined. Using an in vitro model and a gene editing approach, we generated human spermatogonia stem cell-like cells (hSSLCs) from human embryonic stem cells (hESCs) and investigated the role of YAP in human spermatogenesis. The results showed that reducing YAP expression during the early stage of spermatogenic differentiation increased the number of PLZF

Indexed as

Adaptor Proteins, Signal TransducingCell DifferentiationHuman Embryonic Stem CellsSpermatogenesisTranscription FactorsYAP-Signaling ProteinsHumansMalePromyelocytic Leukemia Zinc Finger ProteinSpermatogoniaAdaptor Proteins, Signal TransducingPromyelocytic Leukemia Zinc Finger ProteinTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsHippo signaling pathwayHuman embryonic stem cellsSpermatogenic cell differentiationSpermatogonia stem cellsYAP

Identifiers

PMID38977826
PMCPMC11231333

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.