ArticleNature communications2024
Metal-ligand dual-site single-atom nanozyme mimicking urate oxidase with high substrates specificity.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Next generation smart functionalized nanocomposites for ultrasensitive and real time detection of purine derived metabolic biomarkers.RSC advances · 2026Review
- Advances in ultrasound-mediated nanozyme systems in therapeutic applications.Ultrasonics sonochemistry · 2026Review
- A Biomimetic Single-Atom Nanozyme With a Substrate Pocket for Accurate and Continuous Sweat Glucose Monitoring.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Deciphering the Catalytic Mechanism of Oxidoreductase-Like Nanozymes Along the Reaction Pathway: Activity, Specificity and Sustainability.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Approaching the perfection of natural enzymes: evolution of biomimetic catalytic systems.Science China. Life sciences · 2026Article
- Eco-Nanozymology: A Catalytic Paradigm Integrating Energy, Environment, and Ecology.Nano-micro letters · 2026Review
- Can nanozymes achieve more than enzymes?Nature reviews. Materials · 2026Article
- Application of Single-Atom Nanozymes in the Detection of Small Biomolecules: A Review.Molecules (Basel, Switzerland) · 2026Review
- Colorimetric detection of amino acids enabled by functional nanomaterials: mechanisms, performance evaluation, and translational perspectives.Mikrochimica acta · 2026Review
- Nanozymes for Energy and Environmental Sustainability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Atomically Precise Clusterzymes: A Programmable Optoelectronic Platform for Neuroscience.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Innovative Strategies to Overcome Stability Challenges of Single-Atom Nanozymes.Nano-micro letters · 2026Review
- Precise Catalysis and Immune Activation: New Strategies for Tumor Immunotherapy with Cascade Nanozymes.International journal of nanomedicine · 2026Review
- Bioinspired Design of Heterogenous Single-Atomic-Site Catalysts for Electrocatalysis and Photocatalysis.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Biomedical Applications of Nanozymes: An Enzymology Perspective.Angewandte Chemie (International ed. in English) · 2025Review
- Spatial Coordination Structure-Driven Enzyme-Like Selectivity in Single-Atom Nanozymes.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Bimetallic Cu/Zn Single-Atom Nanozyme with Superoxide Dismutase-Like Activity.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Trimerization of 1,2-Diaminocyclohexane Catalyzed by a Metal-Organic Cage Tandem Catalyst with Dual Biomimetic Active Sites.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
In nature, coenzyme-independent oxidases have evolved in selective catalysis using isolated substrate-binding pockets. Single-atom nanozymes (SAzymes), an emerging type of non-protein artificial enzymes, are promising to simulate enzyme active centers, but owing to the lack of recognition sites, realizing substrate specificity is a formidable task. Here we report a metal-ligand dual-site SAzyme (Ni-DAB) that exhibited selectivity in uric acid (UA) oxidation. Ni-DAB mimics the dual-site catalytic mechanism of urate oxidase, in which the Ni metal center and the C atom in the ligand serve as the specific UA and O
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.