Evidence map›Paper›PMID 38977505›Full record

ArticleInternational journal of legal medicine2024

Integrated Assessment of GFAP and UCH-L1 for their utility in severity assessment and outcome prediction in Traumatic Brain Injury.

Deepu Mathew, Purvi Purohit, Ashita Gadwal, Abhishek Anil, Raghavendra Kumar Sharma, Vikas P Meshram, Puneet Setia

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Article in International journal of legal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Deepu MathewDepartment of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, 342005, India.
Purvi PurohitDepartment of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, 342005, India.
Ashita GadwalDepartment of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, 342005, India.
Abhishek AnilDepartment of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, 342005, India.
Raghavendra Kumar SharmaDepartment of Neurosurgery, All India Institute of Medical Sciences, Jodhpur, Rajasthan, 342005, India.
Vikas P MeshramDepartment of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, 342005, India.
Puneet SetiaDepartment of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, 342005, India. puneetsetia@gmail.com.ORCID http://orcid.org/0000-0002-0849-0759

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to explore the potential of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) as biomarkers for diagnosis and prognosis in mild and severe TBI cases, including TBI-related deaths.

methodsThis prospective cohort study includes 40 cases each of mild, severe, fatal TBI cases, and 40 healthy controls. Serum samples were collected from live patients at 8 and 20 h post injury for UCH-L1 and GFAP respectively, and from deceased patients within 6 h of death.

resultsElevated levels of both GFAP and UCH-L1 were observed in patients with severe and fatal TBI cases. These biomarkers exhibited promising potential for predicting various Glasgow Outcome Scale Extended (GOSE) categories. Combining GFAP and UCH-L1 yielded higher predictive accuracy both for diagnosis and prognosis in TBI cases. The study additionally established specific cut-off levels for GFAP and UCH-L1 stratified according to the severity and prognosis.

conclusionGFAP and UCH-L1 individually demonstrated moderate to good discrimination capacity in predicting TBI severity and functional outcomes. However, combining these biomarkers is recommended for improved diagnostic and prognostic utility. This precision tool can enhance patient care, enabling tailored treatment plans, ultimately reducing morbidity and mortality rates in TBI cases.

Indexed as

BiomarkersBrain Injuries, TraumaticGlial Fibrillary Acidic ProteinUbiquitin ThiolesteraseAdultAgedCase-Control StudiesFemaleGlasgow Outcome ScaleHumansMaleMiddle AgedPrognosisProspective StudiesYoung AdultBiomarkersGFAP protein, humanGlial Fibrillary Acidic ProteinUbiquitin ThiolesteraseUCHL1 protein, humanDiagnostic biomarkerGFAPPrognostic biomarkerTraumatic brain injuryUCH-L1

Identifiers

PMID38977505

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.