Evidence map›Paper›PMID 38977434›Full record

ArticleNeuroradiology2024

Self-expanding intracranial drug-eluting stent system in patients with symptomatic intracranial atherosclerotic stenosis: initial experience and midterm angiographic follow-up.

Feifan Zhang, Jinbiao Yao, Pei Wu, Qiaowei Wu, Chunxu Li, Jinshuo Yang, Yixuan Liu, Ilgiz Gareev, Huaizhang Shi, Chunlei Wang

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Article in Neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Feifan Zhang *Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Youzheng road No.23, Harbin, 150000, Heilongjiang, China.
Jinbiao Yao *Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Youzheng road No.23, Harbin, 150000, Heilongjiang, China.
Pei WuDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Youzheng road No.23, Harbin, 150000, Heilongjiang, China.
Qiaowei WuDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Youzheng road No.23, Harbin, 150000, Heilongjiang, China.
Chunxu LiDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Youzheng road No.23, Harbin, 150000, Heilongjiang, China.
Jinshuo YangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Youzheng road No.23, Harbin, 150000, Heilongjiang, China.
Yixuan LiuDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Youzheng road No.23, Harbin, 150000, Heilongjiang, China.
Ilgiz GareevDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Youzheng road No.23, Harbin, 150000, Heilongjiang, China.
Huaizhang ShiDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Youzheng road No.23, Harbin, 150000, Heilongjiang, China. shihuaizhang@hrbmu.edu.cn.
Chunlei WangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Youzheng road No.23, Harbin, 150000, Heilongjiang, China. chunleikkk@163.com.ORCID http://orcid.org/0000-0002-8069-9792

Funding

Key Laboratory of Highway Construction and Maintenance Technology in the Loess Region of Shanxi Transportation Research Institute 2022ZX06C03Natural Science Foundation of Heilongjiang Province of China YQ2019H05the Foundation of The First Affiliated Hospital of Harbin Medical University 2019L02the Foundation of The First Affiliated Hospital of Harbin Medical University 2023M12The National Natural Science Foundation 81901190
6 · The paper itself

Abstract

backgroundSymptomatic intracranial atherosclerotic stenosis (ICAS) is a major cause of ischemic stroke worldwide. In patients undergoing endovascular treatment for ICAS, in-stent restenosis (ISR) is associated with ischemic stroke recurrence.

objectiveIntracranial drug-eluting self-expanding stent systems (COMETIU; Sinomed Neurovita Technology Inc., CHN) are new devices for treating ICAS. This study evaluated the perioperative experience and medium-term outcomes of COMETIU in 16 patients.

methodsWe prospectively analyzed 16 patients with ICAS (≥ 70% stenosis) who underwent intravascular therapy between September 4, 2022, and February 1, 2023. The primary outcome was the incidence of ISR at 6 months postoperatively. The secondary efficacy outcomes were device and technical success rates. The secondary safety outcomes included stroke or death within 30 days after the procedure and the cumulative annual rate of recurrent ischemic stroke in the target-vessel territory from 31 days to 6 months and 1 year.

resultsA total of 16 patients with 16 intracranial atherosclerotic lesions were treated with 16 COMETIUs. All procedures were performed under general anesthesia with 100% device and technical success rates, with no cases of periprocedural stroke or death. The mean radiographic follow-up duration was at least 6 months postoperatively, and all patients presented for radiographic and clinical follow-up. There were no reported ischemic or hemorrhagic strokes. Angiographic follow-up for all patients revealed no cases of ISR.

conclusionCOMETIU is safe and effective for treating ICAS, with minimal risk during the procedure and a low rate of ISR during medium-term follow-up.

Indexed as

Drug-Eluting StentsIntracranial ArteriosclerosisAgedCerebral AngiographyEndovascular ProceduresFemaleFollow-Up StudiesHumansIschemic StrokeMaleMiddle AgedProspective StudiesTreatment OutcomeAngioplastyIntracranial atherosclerosisStenting, drug-eluting stent

Identifiers

PMID38977434

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.