Evidence map›Paper›PMID 38977334›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Soy isoflavones alleviates calcium overload in rats with cerebral ischemia-reperfusion by inhibiting the Wnt/Ca

L Li, M Wang, S Liu, X Zhang, J Chen, W Tao, S Li, Z Qing, Q Tao, Y Liu and 2 more

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

L LiDepartment of Pathophysiology, Bengbu Medical University, Bengbu 233000, China.
M WangDepartment of Pathophysiology, Bengbu Medical University, Bengbu 233000, China.
S LiuDepartment of Pathophysiology, Bengbu Medical University, Bengbu 233000, China.
X ZhangDepartment of Pathophysiology, Bengbu Medical University, Bengbu 233000, China.
J ChenDepartment of Pathophysiology, Bengbu Medical University, Bengbu 233000, China.
W TaoDepartment of Pathophysiology, Bengbu Medical University, Bengbu 233000, China.
S LiKey Laboratory of Basic and Clinical Cardiovascular and Cerebrovascular Diseases, Bengbu Medical University, Bengbu 233000, China.
Z QingKey Laboratory of Basic and Clinical Cardiovascular and Cerebrovascular Diseases, Bengbu Medical University, Bengbu 233000, China.
Q TaoKey Laboratory of Basic and Clinical Cardiovascular and Cerebrovascular Diseases, Bengbu Medical University, Bengbu 233000, China.
Y LiuKey Laboratory of Basic and Clinical Cardiovascular and Cerebrovascular Diseases, Bengbu Medical University, Bengbu 233000, China.
L HuangDepartment of Pathophysiology, Bengbu Medical University, Bengbu 233000, China.
S ZhaoDepartment of Pathophysiology, Bengbu Medical University, Bengbu 233000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the mechanism by which soybean isoflavone (SI) reduces calcium overload induced by cerebral ischemia-reperfusion (I/R).

methodsForty-eight SD rats were randomized into 4 groups to receive sham operation, cerebral middle artery occlusion for 2 h followed by 24 h of reperfusion (I/R model group), or injection of adeno-associated virus carrying Frizzled-2 siRNA or empty viral vector into the lateral cerebral ventricle after modeling.Western blotting was used to examine Frizzled-2 knockdown efficiency and changes in protein expressions in the Wnt/Ca

resultsIn rats with cerebral I/R, Frizzled-2 knockdown significantly lowered calcium concentration (

conclusionSoy isoflavones can mitigate calcium overload in rats with cerebral I/R by inhibiting the Wnt/Ca

Indexed as

Brain IschemiaCalciumGlycine maxIsoflavonesRats, Sprague-DawleyReperfusion InjuryWnt Signaling PathwayAnimalsApoptosisMaleRatsRNA, Small InterferingWnt-5a ProteinCalciumIsoflavonesRNA, Small InterferingWnt-5a Proteincalcium overloadcerebral ischemia-reperfusionsoy isoflavonesWnt/Ca2+ signaling pathway

Identifiers

PMID38977334
PMCPMC11237289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.