Evidence map›Paper›PMID 38977309›Full record

ArticleGenome research2024

Single-cell analysis reveals transcriptional dynamics in healthy primary parathyroid tissue.

Aarthi Venkat, Maximillian J Carlino, Betty R Lawton, Manju L Prasad, Matthew Amodio, Courtney E Gibson, Caroline J Zeiss, Scott E Youlten, Smita Krishnaswamy, Diane S Krause

Abstract read
In one paragraph

Article in Genome research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aarthi Venkat *Computational Biology and Bioinformatics Program, Yale University, New Haven, Connecticut 06511, USA.ORCID 0000-0003-0298-0172
Maximillian J Carlino *Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.ORCID 0000-0003-1578-8024
Betty R Lawton *Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.ORCID 0000-0002-3164-4605
Manju L PrasadDepartment of Pathology, Yale School of Medicine, New Haven, Connecticut 06520-8023, USA.ORCID 0000-0002-4507-2601
Matthew AmodioDepartment of Computer Science, Yale University, New Haven, Connecticut 06511, USA.
Courtney E GibsonDepartment of Surgery, Yale School of Medicine, New Haven, Connecticut 06520, USA.
Caroline J ZeissDepartment of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA.ORCID 0000-0003-1181-3544
Scott E YoultenDepartment of Genetics, Yale School of Medicine, New Haven, Connecticut 06510, USA.ORCID 0000-0001-9314-2945
Smita Krishnaswamy *Computational Biology and Bioinformatics Program, Yale University, New Haven, Connecticut 06511, USA; diane.krause@yale.edu smita.krishnaswamy@yale.edu.ORCID 0000-0001-5823-1985
Diane S Krause *Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA; diane.krause@yale.edu smita.krishnaswamy@yale.edu.ORCID 0000-0001-9420-6947

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Targeting the inflammatory response in age-related macular degenerationR01EY034234 · NEI · YALE UNIVERSITY · PI Brian P Hafler · 2022 to 2026
$2.0M
Deciphering Genetic and Epigenetic Regulatory Logic of Germ Layer Differentiation with Manifold LearningR01GM130847 · NIGMS · YALE UNIVERSITY · PI KRISHNASWAMY, SMITA · 2019 to 2023
$2.0M
Finding emergent structure in multi-sample biological data with the dual geometry of cells and features R01GM135929 · NIGMS · MICHIGAN STATE UNIVERSITY · PI BROWN, EDWARD · 2019 to 2022
$1.4M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2M
Effects of EBV on autoimmunity and responses to immune therapyR21AI166387 · NIAID · YALE UNIVERSITY · PI HEROLD, KEVAN C · 2021 to 2022
$461k
"Exploration of Human Parathyroid Cellular Organization and Function"R21CA240660 · NCI · YALE UNIVERSITY · PI KRAUSE, DIANE S · 2020 to 2020
$431k
NCATS NIH HHS UL1 TR001863NCI NIH HHS R21 CA240660NEI NIH HHS R01 EY034234NIAID NIH HHS R21 AI166387NIGMS NIH HHS R01 GM130847NIGMS NIH HHS R01 GM135929NIH HHS S10 OD030363
6 · The paper itself

Abstract

Studies on human parathyroids are generally limited to hyperfunctioning glands owing to the difficulty in obtaining normal human tissue. We therefore obtained non-human primate (NHP) parathyroids to provide a suitable alternative for sequencing that would bear a close semblance to human organs. Single-cell RNA expression analysis of parathyroids from four healthy adult

Indexed as

Macaca mulattaParathyroid GlandsSingle-Cell AnalysisAnimalsCell CommunicationChemokinesEpithelial CellsGene Expression ProfilingHumansParathyroid HormoneTranscription, GeneticTranscriptomeChemokinesParathyroid Hormone

Identifiers

PMID38977309
PMCPMC11293540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.