ArticleAJNR. American journal of neuroradiology2024
Predictors of Aneurysm Obliteration in Patients Treated with the WEB Device: Results of a Multicenter Retrospective Study.
Abstract readMulticenter Study
In one paragraph
Article in AJNR. American journal of neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
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5citing papers in PubMed, 2 pooled it
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Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
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- Factors influencing immediate post-angiographic occlusion outcomes in intracranial aneurysms treated with the woven endobridge device: a multi-center analysis and predictive model from the WorldWideWEB consortium.Neurosurgical review · 2025Article
- The Impact of Postprocedural Anticoagulant Use in Patients Undergoing Woven EndoBridge: A Multicenter Propensity Score-Matched Study.Translational stroke research · 2025Article
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Authors and funding
103 authors.
Panagiotis MastorakosFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.ORCID 0000-0003-0505-6938
Kareem El NaamaniFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.ORCID 0000-0001-5294-1003
Nimer AdeebDepartement of Neurosurgery and Neurointerventional Surgery (N.A., M.D., A. Aslan, H.H.C.-S.), Louisiana State University, Shreveport, Lousiana.ORCID 0000-0002-8668-7629
Mathews LanFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.
James CastiglioneFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.
Omaditya KhannaFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.ORCID 0000-0002-6062-5382
Ritam GhoshFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.
Jose Danilo Bengzon DiestroDivision of Diagnostic and Therapeutic Neuroradiology, Department of Radiology, St. Michael's Hospital (J.D.B.D., N.M.C., J.S., V.M.P., A.A.D.), University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-8450-2021
Mahmoud DibasDepartement of Neurosurgery and Neurointerventional Surgery (N.A., M.D., A. Aslan, H.H.C.-S.), Louisiana State University, Shreveport, Lousiana.ORCID 0000-0003-1690-1084
Rachel M McLellanNeuroendovascular Program (R.M.M., J.E.V., J.D.R., N.J.P., C.J.S., M.A.A.-S., A.B.P., A.A.D.), Massachusetts General Hospital and Brigham and Women's Hospital, Harvard University, Boston, Massachusetts.
Oktay AlginDepartment of Radiology (O.A., M.O.O., G.A.), City Hospital, Bilkent, Medical Faculty of Yıldırım Beyazıt University, Ankara, Turkey.ORCID 0000-0002-3877-8366
Sherief GhozyDepartments of Radiology and Neurosurgery (S.G.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0001-5629-3023
Nicole M CancelliereDivision of Diagnostic and Therapeutic Neuroradiology, Department of Radiology, St. Michael's Hospital (J.D.B.D., N.M.C., J.S., V.M.P., A.A.D.), University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-8703-4304
Assala AslanDepartement of Neurosurgery and Neurointerventional Surgery (N.A., M.D., A. Aslan, H.H.C.-S.), Louisiana State University, Shreveport, Lousiana.
Hugo H Cuellar-SaenzDepartement of Neurosurgery and Neurointerventional Surgery (N.A., M.D., A. Aslan, H.H.C.-S.), Louisiana State University, Shreveport, Lousiana.
Sovann V LayService de Neuroradiologie Diagnostique et Thérapeutique (S.V.L.), Centre Hospitalier de Toulouse, Hôpital Purpan, Toulouse, France.ORCID 0000-0003-4105-0664
Adrien GuenegoService de Neuroradiologie Interventionnelle (A.G., S.E., B.T.J., B.L.), Hôpital Universitaire Erasme, Bruxelles, Belgique.ORCID 0000-0001-7281-1652
Leonardo RenieriInterventistica Neurovascolare (L.R., N.L.), Ospedale Careggi di Firenze, Florence, Italy.
Joseph CarnevaleNeurosurgery and Interventional Neuroradiology, Weill Cornell School of Medicine (J. Carnevale, R.W.R., S.B., J.K.), NY Presbyterian Hospital, New York, New York.
Guillaume SaliouService de Radiodiagnostic et Radiologie Interventionnelle (G. Saliou), Centre Hospitalier Vaudois de Lausanne, Lausanne, Switzerland.ORCID 0000-0003-3832-7976
Eimad ShotarDepartment de Neuroradiologie (E.S., K.P., F.C.), Hôpital Pitié-Salpêtrière, Université Sorbonne, Paris, France.ORCID 0000-0002-8712-8431
Kevin PrematDepartment de Neuroradiologie (E.S., K.P., F.C.), Hôpital Pitié-Salpêtrière, Université Sorbonne, Paris, France.ORCID 0000-0003-0705-176X
Markus MöhlenbruchSektion Vaskuläre und Interventionelle Neuroradiologie (M. Möhlenbruch, C.U.), Universitätsklinikum Heidelberg, Heidelberg, Germany.ORCID 0000-0002-5075-704X
Michael KralDepartment of Neurology/Institute of Neurointervention (M.K., M.K.-O., C.J.G.), Christian Doppler University Hospital and Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria.
Justin E VranicNeuroendovascular Program (R.M.M., J.E.V., J.D.R., N.J.P., C.J.S., M.A.A.-S., A.B.P., A.A.D.), Massachusetts General Hospital and Brigham and Women's Hospital, Harvard University, Boston, Massachusetts.ORCID 0000-0002-6000-6709
Charlotte ChungDepartments of Radiology and Neurosurgery (C.C., E.N., E.R., H.A.), NYU Langone Health Center, New York, New York.ORCID 0000-0003-0671-4111
Mohamed M SalemDepartment of Neurosurgery (M.M.S., B.T. Jankowitz, J.-K.B.), University of Pennsylvania Medical Center, Philadelphia, Pennsylvania.ORCID 0000-0001-8483-2995
Ivan LylykEquipo de Neurocirugía Endovascular y Radiología Intervencionista (I.L., P.L.), Clínica La Sagrada Familia, Buenos Aires, Argentina.ORCID 0000-0002-6048-4225
Paul M ForemanNeurosurgery Department (P.M.F., J.A.V.), Orlando Health Neuroscience and Rehabilitation Institute, Orlando, Florida.ORCID 0000-0001-8743-5119
Jay A VachhaniNeurosurgery Department (P.M.F., J.A.V.), Orlando Health Neuroscience and Rehabilitation Institute, Orlando, Florida.ORCID 0000-0002-2446-4315
Hamza ShaikhDepartments of Radiology and Neurosurgery (H.S.), Cooper University Health Care, Cooper Medical School of Rowan University, Camden, New Jersey.
Vedran ŽupančićSubdivision of Interventional Neuroradiology, Department of Radiology (V.Ž.), Clinical Hospital Center Sisters of Mercy, Zagreb, Croatia.
Muhammad U HafeezDepartment of Neurosurgery (M.U.H., P.K., V.K.), UTMB and Baylor School of Medicine, Houston, Texas.
Joshua CatapanoDepartment of Neurosurgery (J. Catapano, A.F.D., F.C.A.), Barrow Neurological Institute, Phoenix, Arizona.
Muhammad WaqasDepartment of Neurosurgery (M.W., V.M.T., A.S.), State University of New York at Buffalo, Buffalo, New York.
Vincent M TutinoDepartment of Neurosurgery (M.W., V.M.T., A.S.), State University of New York at Buffalo, Buffalo, New York.
Mohamed K IbrahimDepartments of Radiology and Neurosurgery (M.K.I., M.A.M., W.B.), Mayo Clinic, Rochester, Minnesota.
Marwa A MohammedDepartments of Radiology and Neurosurgery (M.K.I., M.A.M., W.B.), Mayo Clinic, Rochester, Minnesota.
James D RabinovNeuroendovascular Program (R.M.M., J.E.V., J.D.R., N.J.P., C.J.S., M.A.A.-S., A.B.P., A.A.D.), Massachusetts General Hospital and Brigham and Women's Hospital, Harvard University, Boston, Massachusetts.
Yifan RenInterventional Radiology and Neurointerventional Services, Department of Radiology (Y.R., R.G.T.), Austin Health, Melbourne, Victoria, Australia.
Clemens M SchirmerDepartment of Neurosurgery and Radiology (C.M.S.), Geisinger Hospital, Danville, Pennsylvania.
Mariangela PianoInterventistica Neurovascolare (M. Piano, P.P., G.P.), Ospedale Niguarda Cà Granda, Milano, Italy.
Maria Bres BullrichNeurointerventional Program, Departments of Medical Imaging and Clinical Neurological Sciences (M.B.B., M. Mayich), London Health Sciences Centre, Western University, London, Ontario, Canada.
Michael MayichNeurointerventional Program, Departments of Medical Imaging and Clinical Neurological Sciences (M.B.B., M. Mayich), London Health Sciences Centre, Western University, London, Ontario, Canada.
Anna L KühnDepartment of Neurointerventional Radiology (A.L.K., A.S.P.), UMass Memorial Hospital, Worcester, Massachusetts.
Caterina MichelozziInterventistica Neurovascolare (C.M.), Ospedale San Raffaele Milano, Milano, Italy.
Stéphanie ElensService de Neuroradiologie Interventionnelle (A.G., S.E., B.T.J., B.L.), Hôpital Universitaire Erasme, Bruxelles, Belgique.
Robert M StarkeDepartment of Neurosurgery (R.M.S.), University of Miami, Miami, Florida.
Ameer E HassanDeparment of Neuroscience (A.E.H.), Valley Baptist Neuroscience Institute, Harlingen, Texas.
Mark OgilvieDepartments of Neurosurgery and Radiology (M.O., J.J.), University of Alabama at Birmingham, Birmingham, Alabama.
Anh NguyenDepartment of Diagnostic and Interventional Neuroradiology (A.N., M. Psychogios), University Hospital Basel, Basel, Switzerland.
Jesse JonesDepartments of Neurosurgery and Radiology (M.O., J.J.), University of Alabama at Birmingham, Birmingham, Alabama.
Waleed BrinjikjiDepartments of Radiology and Neurosurgery (M.K.I., M.A.M., W.B.), Mayo Clinic, Rochester, Minnesota.
Marios PsychogiosDepartment of Diagnostic and Interventional Neuroradiology (A.N., M. Psychogios), University Hospital Basel, Basel, Switzerland.
Christian UlfertSektion Vaskuläre und Interventionelle Neuroradiologie (M. Möhlenbruch, C.U.), Universitätsklinikum Heidelberg, Heidelberg, Germany.
Julian SpearsDivision of Diagnostic and Therapeutic Neuroradiology, Department of Radiology, St. Michael's Hospital (J.D.B.D., N.M.C., J.S., V.M.P., A.A.D.), University of Toronto, Toronto, Ontario, Canada.
Brian T JankowitzDepartment of Neurosurgery (M.M.S., B.T. Jankowitz, J.-K.B.), University of Pennsylvania Medical Center, Philadelphia, Pennsylvania.
Jan-Karl BurkhardtDepartment of Neurosurgery (M.M.S., B.T. Jankowitz, J.-K.B.), University of Pennsylvania Medical Center, Philadelphia, Pennsylvania.
Ricardo A DomingoDepartments of Radiology & Neurosurgery (R.A.D., T.H.), Mayo Clinic, Jacksonville, Florida.
Thien HuynhDepartments of Radiology & Neurosurgery (R.A.D., T.H.), Mayo Clinic, Jacksonville, Florida.
Rabih G TawkInterventional Radiology and Neurointerventional Services, Department of Radiology (Y.R., R.G.T.), Austin Health, Melbourne, Victoria, Australia.
Boris LubiczService de Neuroradiologie Interventionnelle (A.G., S.E., B.T.J., B.L.), Hôpital Universitaire Erasme, Bruxelles, Belgique.
Marie T NawkaDepartment of Diagnostic and Interventional Neuroradiology (M.T.N.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Pietro PanniInterventistica Neurovascolare (M. Piano, P.P., G.P.), Ospedale Niguarda Cà Granda, Milano, Italy.
Ajit S PuriDepartment of Neurointerventional Radiology (A.L.K., A.S.P.), UMass Memorial Hospital, Worcester, Massachusetts.
Guglielmo PeroInterventistica Neurovascolare (M. Piano, P.P., G.P.), Ospedale Niguarda Cà Granda, Milano, Italy.
Erez NossekDepartments of Radiology and Neurosurgery (C.C., E.N., E.R., H.A.), NYU Langone Health Center, New York, New York.
Eytan RazDepartments of Radiology and Neurosurgery (C.C., E.N., E.R., H.A.), NYU Langone Health Center, New York, New York.
Monika Killer-OberpfalzerDepartment of Neurology/Institute of Neurointervention (M.K., M.K.-O., C.J.G.), Christian Doppler University Hospital and Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria.
M Ozgur OzatesDepartment of Radiology (O.A., M.O.O., G.A.), City Hospital, Bilkent, Medical Faculty of Yıldırım Beyazıt University, Ankara, Turkey.
Giyas AyberkDepartment of Radiology (O.A., M.O.O., G.A.), City Hospital, Bilkent, Medical Faculty of Yıldırım Beyazıt University, Ankara, Turkey.
Robert W RegenhardtNeurosurgery and Interventional Neuroradiology, Weill Cornell School of Medicine (J. Carnevale, R.W.R., S.B., J.K.), NY Presbyterian Hospital, New York, New York.
Christoph J GriessenauerDepartment of Neurology/Institute of Neurointervention (M.K., M.K.-O., C.J.G.), Christian Doppler University Hospital and Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria.
Hamed AsadiDepartments of Radiology and Neurosurgery (C.C., E.N., E.R., H.A.), NYU Langone Health Center, New York, New York.
Adnan SiddiquiDepartment of Neurosurgery (M.W., V.M.T., A.S.), State University of New York at Buffalo, Buffalo, New York.
Andrew F DucruetDepartment of Neurosurgery (J. Catapano, A.F.D., F.C.A.), Barrow Neurological Institute, Phoenix, Arizona.
Felipe C AlbuquerqueDepartment of Neurosurgery (J. Catapano, A.F.D., F.C.A.), Barrow Neurological Institute, Phoenix, Arizona.
Nirav J PatelNeuroendovascular Program (R.M.M., J.E.V., J.D.R., N.J.P., C.J.S., M.A.A.-S., A.B.P., A.A.D.), Massachusetts General Hospital and Brigham and Women's Hospital, Harvard University, Boston, Massachusetts.
Christopher J StapletonNeuroendovascular Program (R.M.M., J.E.V., J.D.R., N.J.P., C.J.S., M.A.A.-S., A.B.P., A.A.D.), Massachusetts General Hospital and Brigham and Women's Hospital, Harvard University, Boston, Massachusetts.
Peter KanDepartment of Neurosurgery (M.U.H., P.K., V.K.), UTMB and Baylor School of Medicine, Houston, Texas.
Vladimir KalousekDepartment of Neurosurgery (M.U.H., P.K., V.K.), UTMB and Baylor School of Medicine, Houston, Texas.
Pedro LylykEquipo de Neurocirugía Endovascular y Radiología Intervencionista (I.L., P.L.), Clínica La Sagrada Familia, Buenos Aires, Argentina.
Srikanth BodduNeurosurgery and Interventional Neuroradiology, Weill Cornell School of Medicine (J. Carnevale, R.W.R., S.B., J.K.), NY Presbyterian Hospital, New York, New York.
Jared KnopmanNeurosurgery and Interventional Neuroradiology, Weill Cornell School of Medicine (J. Carnevale, R.W.R., S.B., J.K.), NY Presbyterian Hospital, New York, New York.
Mohammad A Aziz-SultanNeuroendovascular Program (R.M.M., J.E.V., J.D.R., N.J.P., C.J.S., M.A.A.-S., A.B.P., A.A.D.), Massachusetts General Hospital and Brigham and Women's Hospital, Harvard University, Boston, Massachusetts.
Frédéric ClarençonDepartment de Neuroradiologie (E.S., K.P., F.C.), Hôpital Pitié-Salpêtrière, Université Sorbonne, Paris, France.
Nicola LimbucciInterventistica Neurovascolare (L.R., N.L.), Ospedale Careggi di Firenze, Florence, Italy.
Mario ZanatyFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.
Juan Carlos Martinez-GutierrezDepartment of Neurology (J.C.M.-G., S.S., G. Spiegel), UTHealth McGovern Medical School, Houston, Texas.
Sunil ShethDepartment of Neurology (J.C.M.-G., S.S., G. Spiegel), UTHealth McGovern Medical School, Houston, Texas.
Gary SpiegelDepartment of Neurology (J.C.M.-G., S.S., G. Spiegel), UTHealth McGovern Medical School, Houston, Texas.
Rawad AbbasFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.
Abdelaziz AmllayFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.
Stavropoula I TjoumakarisFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.
Michael R GoochFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.
Nabeel A HerialFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.
Robert H RosenwasserFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.
Hekmat ZarzourFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.
Richard F SchmidtFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.
Vitor Mendes PereiraDivision of Diagnostic and Therapeutic Neuroradiology, Department of Radiology, St. Michael's Hospital (J.D.B.D., N.M.C., J.S., V.M.P., A.A.D.), University of Toronto, Toronto, Ontario, Canada.
Aman B PatelNeuroendovascular Program (R.M.M., J.E.V., J.D.R., N.J.P., C.J.S., M.A.A.-S., A.B.P., A.A.D.), Massachusetts General Hospital and Brigham and Women's Hospital, Harvard University, Boston, Massachusetts.
Pascal M JabbourFrom the Department of Neurosurgery (P.M., K.E.N., M.L., J. Castiglione, O.K., R.G., M.Z., R.A., A. Amllay, S.I.T., M.R.G., N.A.H., R.H.R., H.Z., R.F.S., P.M.J.), Thomas Jefferson University, Philadelphia, Pennsylvania.
Adam A DmytriwDivision of Diagnostic and Therapeutic Neuroradiology, Department of Radiology, St. Michael's Hospital (J.D.B.D., N.M.C., J.S., V.M.P., A.A.D.), University of Toronto, Toronto, Ontario, Canada admytriw@mgh.harvard.edu.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeDespite the numerous studies evaluating the occlusion rates of aneurysms following WEB embolization, there are limited studies identifying predictors of occlusion. Our purpose was to identify predictors of aneurysm occlusion and the need for retreatment. MATERIALS AND
methodsThis is a review of a prospectively maintained database across 30 academic institutions. We included patients with previously untreated cerebral aneurysms embolized using the WEB who had available intraprocedural data and long-term follow-up.
resultsWe studied 763 patients with a mean age of 59.9 (SD, 11.7) years. Complete aneurysm occlusion was observed in 212/726 (29.2%) cases, and contrast stasis was observed in 485/537 (90.3%) of nonoccluded aneurysms. At the final follow-up, complete occlusion was achieved in 497/763 (65.1%) patients, and retreatment was required for 56/763 (7.3%) patients. On multivariable analysis, history of smoking, maximal aneurysm diameter, and the presence of an aneurysm wall branch were negative predictors of complete occlusion (OR, 0.5, 0.8, and 0.4, respectively). Maximal aneurysm diameter, the presence of an aneurysm wall branch, posterior circulation location, and male sex increase the chances of retreatment (OR, 1.2, 3.8, 3.0, and 2.3 respectively). Intraprocedural occlusion resulted in a 3-fold increase in the long-term occlusion rate and a 5-fold decrease in the retreatment rate (
conclusionsIntraprocedural occlusion can be used to predict the chance of long-term aneurysm occlusion and the need for retreatment after embolization with a WEB device. Smoking, aneurysm size, and the presence of an aneurysm wall branch are associated with decreased chances of successful treatment.
Indexed as
Embolization, TherapeuticIntracranial AneurysmAgedFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsTreatment Outcome
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