Evidence map›Paper›PMID 38977240›Full record

Observational studyInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2024

Association between chlorine-treated drinking water, the gut microbiome, and enteric pathogen burden in young children in Haiti: An observational study.

Denise Chac, Damien M Slater, Yodeline Guillaume, Chelsea N Dunmire, Ralph Ternier, Kenia Vissières, Stanley Juin, Mentor Ali Ber Lucien, Jacques Boncy, Vanessa M Sanchez and 9 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Denise ChacDepartment of Medicine, University of Washington, Seattle, WA, USA.
Damien M SlaterDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
Yodeline GuillaumeCenter for Global Health, Massachusetts General Hospital, Boston, MA, USA.
Chelsea N DunmireDepartment of Medicine, University of Washington, Seattle, WA, USA.
Ralph TernierPartners In Health/Zanmi Lasante, Croix des Bouquets, Haiti.
Kenia VissièresPartners In Health/Zanmi Lasante, Croix des Bouquets, Haiti.
Stanley JuinUnited States Centers for Disease Control and Prevention, Port-au-Prince, Haiti.
Mentor Ali Ber LucienNational Laboratory of Public Health, Port-au-Prince, Haiti.
Jacques BoncyNational Laboratory of Public Health, Port-au-Prince, Haiti.
Vanessa M SanchezDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
Mia G DumayasDepartment of Medicine, University of Washington, Seattle, WA, USA.
Gertrude Cene AugustinPartners In Health/Zanmi Lasante, Croix des Bouquets, Haiti.
Taufiqur R BhuiyanInternational Center for Diarrheal Disease Research, Bangladesh, Vaccine Sciences, Dhaka, Bangladesh.
Firdausi QadriInternational Center for Diarrheal Disease Research, Bangladesh, Vaccine Sciences, Dhaka, Bangladesh.
Fahima ChowdhuryInternational Center for Diarrheal Disease Research, Bangladesh, Vaccine Sciences, Dhaka, Bangladesh.
Ashraful I KhanInternational Center for Diarrheal Disease Research, Bangladesh, Vaccine Sciences, Dhaka, Bangladesh.
Ana A WeilDepartment of Medicine, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA. Electronic address: anaweil@uw.edu.
Louise C IversCenter for Global Health, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Jason B HarrisDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Center for Global Health, Massachusetts General Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

Funding

Immune Responses to Vibrio cholerae infection and vaccination in HaitiR01AI099243 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HARRIS, JASON B, IVERS, LOUISE C. · 2012 to 2022
$7.9M
The gut microbiome and susceptibility to Vibrio choleraeK08AI123494 · NIAID · UNIVERSITY OF WASHINGTON · PI WEIL, ANA A · 2016 to 2020
$967k
NIAID NIH HHS K08 AI123494NIAID NIH HHS R01 AI099243
6 · The paper itself

Abstract

objectiveThe effects of sanitation and hygiene interventions on the gut microbiome and enteric pathogen burden are not well understood. We measured the association between free chlorine residue (FCR) levels in drinking water, microbiome composition, and stool enteric pathogens in infants and young children in Haiti.

methodsFCR levels were measured in household drinking water and enteric pathogen burden was evaluated using multiplex RT-PCR of stool among 131 children from one month to five years of age living in Mirebalais, Haiti. Microbiome profiling was performed using metagenomic sequencing.

resultsMost individuals lived in households with undetectable FCR measured in the drinking water (112/131, 86%). Detection of enteric pathogen DNA in stool was common and did not correlate with household water FCR. The infant microbiome in households with detectable FCR demonstrated reduced richness (fewer total number of species, P = 0.04 Kruskall-Wallis test) and less diversity by Inverse Simpson measures (P = 0.05) than households with undetectable FCR. Infants in households with a detectable FCR were more likely to have abundant Bifidobacterium. Using in vitro susceptibility testing, we found that some Bifidobacterium species were resistant to chlorine.

conclusionsFCR in household drinking water did not correlate with enteric pathogen burden in our study.

Indexed as

ChlorineDrinking WaterFecesGastrointestinal MicrobiomeChild, PreschoolFemaleHaitiHumansInfantMaleWater PurificationChlorineDrinking WaterChlorineFree chlorine residualGut microbiomeInfant microbiome

Identifiers

PMID38977240
PMCPMC11500667

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.