Evidence map›Paper›PMID 38977017›Full record

ArticleNature2024

Pathogenicity and transmissibility of bovine H5N1 influenza virus.

Amie J Eisfeld, Asim Biswas, Lizheng Guan, Chunyang Gu, Tadashi Maemura, Sanja Trifkovic, Tong Wang, Lavanya Babujee, Randall Dahn, Peter J Halfmann and 8 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 187 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Detection of highly pathogenic avian influenza A(H5N1) virus, clade 2.3.4.4b, genotype B3.13 in placentas from aborted bovine fetuses.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2026
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127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Amie J Eisfeld *Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Asim Biswas *Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Lizheng Guan *Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Chunyang Gu *Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Tadashi Maemura *Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Sanja TrifkovicInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Tong WangInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Lavanya BabujeeInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Randall DahnInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Peter J HalfmannInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-1648-1625
Tera BarnhardtHeritage Vet Partners, Johnson, KS, USA.
Gabriele NeumannInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Yasuo SuzukiDepartment of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Alexis ThompsonTexas A&M Veterinary Medical Diagnostic Laboratory, Canyon, TX, USA.ORCID 0000-0003-4405-5313
Amy K SwinfordTexas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA.
Kiril M DimitrovTexas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA.ORCID 0000-0002-5525-4492
Keith PoulsenWisconsin Veterinary Diagnostic Laboratory, University of Wisconsin-Madison, Madison, WI, USA.
Yoshihiro KawaokaInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA. yoshihiro.kawaoka@wisc.edu.ORCID 0000-0001-5061-8296

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6M
Centers of Excellence for Influenza Research and ResponseJapan Agency for Medical Research and DevelopmentNIAID NIH HHS 75N93021C00014Wisconsin Department of Agriculture, Trade and Consumer Protection
6 · The paper itself

Abstract

Highly pathogenic H5N1 avian influenza (HPAI H5N1) viruses occasionally infect, but typically do not transmit, in mammals. In the spring of 2024, an unprecedented outbreak of HPAI H5N1 in bovine herds occurred in the USA, with virus spread within and between herds, infections in poultry and cats, and spillover into humans, collectively indicating an increased public health risk

Indexed as

Cattle DiseasesInfluenza A Virus, H5N1 SubtypeOrthomyxoviridae InfectionsVirulenceAnimalsCattleFemaleFerretsHumansInfluenza, HumanLaryngeal MasksMammary Glands, AnimalMiceMice, Inbred BALB CMilkSeroconversionSialic Acids

Identifiers

PMID38977017
PMCPMC11390473

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.