ArticleAnalytical chemistry2024
Modeling Ligand Exchange Kinetics in Iridium Complexes Catalyzing SABRE Nuclear Spin Hyperpolarization.
Article in Analytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Metal coordination at biological interfaces: Mechanisms, therapeutics, and translation.Materials today. Bio · 2026Review
- Nonresonant SABRE provides an additional versatile hyperpolarization approach in magnetic resonance.Science advances · 2026Article
- Machine learning-assisted molecular design for efficientChemical science · 2026Article
- Mechanistic insights into chemical exchange during the signal amplification by reversible exchange sensitization of pyruvate.Nature communications · 2026Article
- Hyperpolarization of [1-Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Field Cycling from 10 nT to 9.4 T: A Flexible Gear Rod Design for Nuclear Spin Relaxation and Hyperpolarization Studies.ACS measurement science au · 2026Article
- A Controlled System for Parahydrogen Hyperpolarization Experiments.Molecules (Basel, Switzerland) · 2025Article
- Analysis of chemical exchange in iridium N-heterocyclic carbene complexes using heteronuclear parahydrogen-enhanced NMR.Communications chemistry · 2024Article
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Authors and funding
8 authors.
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Abstract
Large signal enhancements can be obtained for NMR analytes using the process of nuclear spin hyperpolarization. Organometallic complexes that bind parahydrogen can themselves become hyperpolarized. Moreover, if parahydrogen and a to-be-hyperpolarized analyte undergo chemical exchange with the organometallic complex it is possible to catalytically sensitize the detection of the analyte via hyperpolarization transfer through spin-spin coupling in this organometallic complex. This process is called Signal Amplification By Reversible Exchange (SABRE). Signal intensity gains of several orders of magnitude can thus be created for various compounds in seconds. The chemical exchange processes play a defining role in controlling the efficiency of SABRE because the lifetime of the complex must match the spin-spin couplings. Here, we show how analyte dissociation rates in the key model substrates pyridine (the simplest six-membered heterocycle), 4-aminopyridine (a drug), and nicotinamide (an essential vitamin biomolecule) can be examined. This is achieved for the most widely employed SABRE motif that is based on IrIMes-derived catalysts by
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