Evidence map›Paper›PMID 38976727›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

A wound-induced differentiation trajectory for neurons.

Ryan E Hulett, Carlos Rivera-López, Andrew R Gehrke, Annika Gompers, Mansi Srivastava

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Distributed neural computation and the evolution of the first brains.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. The role(s) of NF-Y in development and differentiation.Cell death and differentiation · 2025
    Review
  8. Making Neurobots and Chimerical Ctenophores.bioRxiv : the preprint server for biology · 2024
    Article
  9. The role ofbioRxiv : the preprint server for biology · 2024
    Article
  10. The Role ofIntegrative organismal biology (Oxford, England) · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Ryan E Hulett *Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138.ORCID 0000-0001-9288-7099
Carlos Rivera-LópezDepartment of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138.ORCID 0000-0002-8823-2230
Andrew R GehrkeDepartment of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138.
Annika GompersDepartment of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138.
Mansi SrivastavaDepartment of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138.

Funding

Joint Program in Molecules, Cells, and OrganismsT32GM135143 · NIGMS · HARVARD UNIVERSITY · PI D'SOUZA, VICTORIA MANUEL · 2020 to 2024
$3.2M
Using a new regenerative model system to elucidate mechanisms for stem cell regulationR35GM128817 · NIGMS · HARVARD UNIVERSITY · PI SRIVASTAVA, MANSI · 2018 to 2022
$2.1M
Stem cell regulation during development and whole-body regenerationR35GM153252 · NIGMS · HARVARD UNIVERSITY · PI Mansi Srivastava · 2024 to 2026
$1.4M
Identifying genetic pathways and cellular sources for neural regeneration in adult animalsF31GM134633 · NIGMS · HARVARD UNIVERSITY · PI HULETT, RYAN EDWARD · 2020 to 2021
$63k
HHS | NIH | National Institute of General Medical Sciences (NIGMS) 1F31GM134633-01A1HHS | NIH | National Institute of General Medical Sciences (NIGMS) 1R35GM128817National Science Foundation (NSF) IOS 1652104NIGMS NIH HHS F31 GM134633NIGMS NIH HHS R35 GM128817NIGMS NIH HHS R35 GM153252NIGMS NIH HHS T32 GM135143NSF | National Science Foundation Graduate Research Fellowship Program (GRFP) 2020296625
6 · The paper itself

Abstract

Animals capable of whole-body regeneration can replace any missing cell type and regenerate fully functional new organs, including new brains, de novo. The regeneration of a new brain requires the formation of diverse neural cell types and their assembly into an organized structure with correctly wired circuits. Recent work in various regenerative animals has revealed transcriptional programs required for the differentiation of distinct neural subpopulations, however, how these transcriptional programs are initiated in response to injury remains unknown. Here, we focused on the highly regenerative acoel worm,

Indexed as

Cell DifferentiationNeuronsAnimalsBrainRegenerationfunctional genomicsneural differentiationregenerationstem cellswound response

Identifiers

PMID38976727
PMCPMC11260127

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.