Evidence map›Paper›PMID 38976571›Full record

Trial reportAIDS care2024

Acceptability, feasibility and preliminary effectiveness of the mHealth intervention, InTSHA, on retention in care and viral suppression among adolescents with HIV in South Africa: a pilot randomized clinical trial.

Brian C Zanoni, Moherndran Archary, Thobekile Sibaya, Nicholas Musinguzi, Casiel T Gethers, Madeleine Goldstein, Scarlett Bergam, Christina Psaros, Vincent C Marconi, Jessica E Haberer

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
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  7. Health services' responses to transitioning adolescents to adult HIV care in South Africa.African journal of primary health care & family medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brian C ZanoniEmory University School of Medicine, Atlanta, GA, USA.
Moherndran ArcharyUniversity of KwaZulu-Natal Nelson Mandela School of Medicine, Durban, South Africa.
Thobekile SibayaUniversity of KwaZulu-Natal Nelson Mandela School of Medicine, Durban, South Africa.
Nicholas MusinguziGlobal Health Collaborative, Mbarara, Uganda.
Casiel T GethersEmory University School of Medicine, Atlanta, GA, USA.
Madeleine GoldsteinEmory University School of Medicine, Atlanta, GA, USA.
Scarlett BergamUniversity of KwaZulu-Natal Nelson Mandela School of Medicine, Durban, South Africa.
Christina PsarosMassachusetts General Hospital, Boston, MA, USA.
Vincent C MarconiEmory University School of Medicine, Atlanta, GA, USA.
Jessica E HabererMassachusetts General Hospital, Boston, MA, USA.

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Optimizing mHealth for adherence monitoring and interventionK24MH114732 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI HABERER, JESSICA ELIZABETH · 2017 to 2021
$800k
INTSHA: INTERACTIVE TRANSITION SUPPORT FOR HIV-INFECTED ADOLESCENTS USING SOCIAL MEDIAK23MH114771 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ZANONI, BRIAN C. · 2018 to 2021
$778k
NIAID NIH HHS P30 AI050409NIMH NIH HHS K23 MH114771NIMH NIH HHS K24 MH114732
6 · The paper itself

Abstract

We describe the results of a pilot randomized clinical trial of a mobile phone-based intervention, InTSHA: Interactive Transition Support for Adolescents with HIV, compared to standard care. Encrypted, closed group chats delivered via WhatsApp provided peer support and improved communication between adolescents with HIV, their caregivers, and healthcare providers. We randomized 80 South African adolescents ages 15 to 19 years with perinatally-acquired HIV to receive either the intervention (n=40) or standard of care (n=40). We measured acceptability (Acceptability of Intervention Measure [AIM]) and feasibility (Feasibility of Intervention Measure [FIM]) as primary outcomes. We evaluated impact on retention in care and viral suppression six months after randomization as secondary endpoints. We performed bivariable and multivariable analyses using logistic regression models to assess the effect of the InTSHA intervention compared to standard of care. Among the adolescents randomized to the InTSHA intervention, the median AIM was 4.1/5.0 (82%) and median FIM was 3.9/5.0 (78%). We found no difference in retention in care or in viral suppression comparing intervention and control groups. Among adolescents who attended three or more sessions, retention in care was 100% at 6 months. InTSHA is an acceptable and feasible mHealth intervention warranting further study in a larger population.

Indexed as

Feasibility StudiesHIV InfectionsPatient Acceptance of Health CareRetention in CareTelemedicineAdolescentCell PhoneFemaleHumansMalePilot ProjectsSouth AfricaViral LoadYoung AdultadolescentHIV transition supportMHealthSDG 3: Good health and well-beingSDG 4: Quality educationSouth Africa

Identifiers

PMID38976571
PMCPMC11269015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.