Evidence map›Paper›PMID 38976202›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2024

The Protective Effect of Juçara Fruit (Euterpe edulis Martius) Extracts on LPS-Activated J774 Macrophages.

Mayara Schulz, Luciano Valdemiro Gonzaga, Ana Clara Nascimento Antunes, Tainá Lubschinski, Eduarda Talita Bramorski Mohr, Eduardo Monguilhott Dalmarco, Carolina Turnes Pasini Deolindo, Rodrigo Barcellos Hoff, Fábio Martinho Zambonim, Ana Carolina Oliveira Costa and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mayara SchulzDepartment of Food Science and Technology, Federal University of Santa Catarina, Admar Gonzaga 1346, Itacorubi, Florianopolis, SC, 88034-001, Brazil. schulzmay@gmail.com.
Luciano Valdemiro GonzagaDepartment of Food Science and Technology, Federal University of Santa Catarina, Admar Gonzaga 1346, Itacorubi, Florianopolis, SC, 88034-001, Brazil.
Ana Clara Nascimento AntunesDepartment of Food Science and Technology, Federal University of Santa Catarina, Admar Gonzaga 1346, Itacorubi, Florianopolis, SC, 88034-001, Brazil.
Tainá LubschinskiDepartment of Clinical Analysis, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
Eduarda Talita Bramorski MohrDepartment of Clinical Analysis, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
Eduardo Monguilhott DalmarcoDepartment of Clinical Analysis, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
Carolina Turnes Pasini DeolindoFederal Agricultural Defense Laboratory, Brazilian Ministry of Agriculture, Livestock and Food Supply, São José, SC, 91780-580, Brazil.
Rodrigo Barcellos HoffFederal Agricultural Defense Laboratory, Brazilian Ministry of Agriculture, Livestock and Food Supply, São José, SC, 91780-580, Brazil.
Fábio Martinho ZambonimAgricultural Research and Rural Extension Company of Santa Catarina (Epagri)/ Environmental Resources and Hydrometeorology Information Center (Ciram), Florianópolis, SC, 88034-901, Brazil.
Ana Carolina Oliveira CostaDepartment of Food Science and Technology, Federal University of Santa Catarina, Admar Gonzaga 1346, Itacorubi, Florianopolis, SC, 88034-001, Brazil.
Roseane FettDepartment of Food Science and Technology, Federal University of Santa Catarina, Admar Gonzaga 1346, Itacorubi, Florianopolis, SC, 88034-001, Brazil. roseane.fett@gmail.com.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 165753/2020-0
6 · The paper itself

Abstract

This study investigated the anti-inflammatory effect of hydrophilic and lipophilic extracts from juçara fruits (Euterpe edulis Martius) through measurement of nitric oxide (NOx) and cytokines (IL-12p70, TNF-α, INF-γ, MCP-1, IL-6, and IL-10). J774 macrophages were stimulated with lipopolysaccharides (1 µg/mL) and treated with various concentrations (1-100 µg/mL) of juçara fruits extracts from crude extracts, and hexane, dichloromethane, ethyl acetate, and butanol fractions. Potential relationships between the phenolic composition of the extracts determined by LC-ESI-MS/MS and their anti-inflammatory capacity were also evaluated. Hexane and dichloromethane fractions inhibited NOx and IL-12p70 while increased IL-10. Hexane fractions also decreased IL-6 and IFN-γ production. Hexane and dichloromethane fractions showed a higher number of phenolic compounds (32 and 34, respectively) than the other extracts tested and were also the only ones that presented benzoic acid and pinocembrin. These results suggest juçara fruits compounds as potential anti-inflammatory agents, especially those of a more apolar nature.

Indexed as

Anti-Inflammatory AgentsFruitLipopolysaccharidesMacrophagesNitric OxidePlant ExtractsAnimalsCell LineCytokinesMicePhenolsAnti-Inflammatory AgentsCytokinesLipopolysaccharidesNitric OxidePhenolsPlant ExtractsAçaíAnti-inflammatoryCytokinesInflammationNitric OxidePhenolic Compounds

Identifiers

PMID38976202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.