Evidence map›Paper›PMID 38976200›Full record

ReviewCurrent allergy and asthma reports2024

Food-Pollen Cross-Reactivity and its Molecular Diagnosis in China.

Lan Zhao, Tingting Ma, Xiaoyan Wang, Hongtian Wang, Yi Liu, Shandong Wu, Linglin Fu, Luud Gilissen, Ronald van Ree, Xueyan Wang and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current allergy and asthma reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. [Epidemiological investigation and risk factors analysis of allergic rhinitis induced by Artemisia pollen in northern China].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Article
  3. Review
  4. Pollen-Food Allergy Syndrome in China: Current Knowledge and Future Research Needs.International archives of allergy and immunology · 2026
    Review
  5. [Pollen-food allergy syndrome: association between allergen cross-reactivity and symptom severity].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  6. Food Allergy in Children in China.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025
    Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lan Zhao *Allergy Research Center, Zhejiang University, Hangzhou, 310058, China.
Tingting Ma *Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Xiaoyan Wang *Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Hongtian WangDepartment of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Yi LiuHangzhou Zheda Dixun Biological Gene Engineering Co. Ltd, Hangzhou, China.
Shandong WuHangzhou Zheda Dixun Biological Gene Engineering Co. Ltd, Hangzhou, China.
Linglin FuSchool of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China.
Luud GilissenPlant Breeding, Wageningen University & Research, Wageningen, The Netherlands.
Ronald van ReeDepartments of Experimental Immunology and of Otorhinolaryngology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Xueyan WangDepartment of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. wangxueyan2018@163.com.
Zhongshan GaoAllergy Research Center, Zhejiang University, Hangzhou, 310058, China. gaozhongshan@zju.edu.cn.

Funding

Science and Technology Plan "Open list" project of Ordos City JBGS-2021-006Talent Cultivation Project of Beijing Shijitan Hospital, Capital Medical University during the "14th Five Year Plan" Period 2023LJRCWXYThe National Natural Science Foundation of China 32302482
6 · The paper itself

Abstract

purpose of reviewPlant-derived foods are one of the most common causative sources of food allergy in China, with a significant relationship to pollinosis. This review aims to provide a comprehensive overview of this food-pollen allergy syndrome and its molecular allergen diagnosis to better understand the cross-reactive basis. RECENT

findingsFood-pollen cross-reactivity has been mainly reported in Northern China, Artemisia pollen is the major related inhalant source, followed by tree pollen (Betula), while grass pollen plays a minor role. Pollen allergy is relatively low in Southern China, with allergies to grass pollen being more important than weed and tree pollens. Rosaceae fruits and legume seeds stand out as major related allergenic foods. Non-specific lipid transfer protein (nsLTP) has been found to be the most clinically relevant cross-reacting allergenic component, able to induce severe reactions. PR-10, profilin, defensin, chitinase, and gibberellin-regulated proteins are other important cross-reactive allergen molecules. Artemisia pollen can induce allergenic cross-reactions with a wide range of plant-derived foods in China, and spring tree pollens (Betula) are also important. nsLTP found in both pollen and plant-derived food is considered the most significant allergen in food pollen cross-reactivity. Component-resolved diagnosis with potential allergenic proteins is recommended to improve diagnostic accuracy and predict the potential risk of causing allergic symptoms.

Indexed as

AllergensCross ReactionsFood HypersensitivityPollenAntigens, PlantArtemisiaChinaHumansPlant ProteinsRhinitis, Allergic, SeasonalAllergensAntigens, PlantPlant ProteinsComponent resolved diagnosis (CRD)Cross Reactivity sIgEPollen food allergy syndrome

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.