ArticleAbdominal radiology (New York)2025
Diagnostic accuracy and reliability of CT-based Node-RADS for colon cancer.
Article in Abdominal radiology (New York), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- CT diagnostic performance for preoperative staging of colon cancer: a systematic review and meta-analysis.European radiology · 2026Pooled it
- Diagnostic accuracy of CT for identifying high-risk colon cancer: a systematic review and meta-analysis.European radiology · 2026Pooled it
- CT-based Node-RADS for metastatic lymph node detection in colon cancer and influence of microsatellite instability.Abdominal radiology (New York) · 2026Article
- Assessment of inter-reader agreement and diagnostic performance of Node-RADS in colon cancer.Insights into imaging · 2026Article
- Node-RADS in cervical cancer: a multi-reader agreement and diagnostic performance study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Node-RADS for preoperative locoregional nodal staging of endometrial cancer: reproducibility and accuracy assessment using CT and MRI.European radiology · 2026Article
- Factors associated with lymph node metastasis and survival in T2 colon cancer.BMC gastroenterology · 2025Article
- Node Reporting and Data System 1.0 (Node-RADS) for the Assessment of Oncological Patients' Lymph Nodes in Clinical Imaging.Journal of clinical medicine · 2025Review
- Article
- Diagnostic Accuracy and Reliability of CT-based Node-RADS for Esophageal Cancer.In vivo (Athens, Greece)Article
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9 authors.
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Abstract
objectiveThe Node-RADS classification was recently published as a classification system to better characterize lymph nodes in oncological imaging. The present analysis investigated the diagnostic benefit of the Node-RADS classification of staging computed tomography (CT) images to categorize and stage lymph nodes in patients with colon cancer. MATERIALS AND
methodsAll patients were surgically resected and the lymph nodes were histopathological analyzed. All investigated lymph nodes were scored in accordance to the Node-RADS classification by two experienced radiologists. Interreader variability was assessed with Cohen's kappa analysis, discrimination analysis was performed with Mann-Whitney-U test and diagnostic accuracy was assessed with receiver-operating characteristics (ROC) curve analysis.
resultsOverall, 108 patients (n = 49 females, 45.3%) with a mean age of 70.08 ± 14.34 years were included. In discrimination analysis, the total Node-RADS score showed statistically significant differences between N- and N + stage (for reader 1: mean 1.89 ± 1.09 score for N- versus 2.93 ± 1.62 score for N+, for reader 2: 1.33 ± 0.48 score for N- versus 3.65 ± 0.94 score for N+, p = 0.001, respectively). ROC curve analysis for lymph node discrimination showed an area under the curve of 0.68. A threshold value of 2 resulted in a sensitivity of 0.62 and a specificity of 0.71.
conclusionNode-RADS score derived from staging CT shows only limited diagnostic accuracy to correctly predict nodal positivity in colon cancer. The interreader variability seems to be high and should question the clinical translation for this tumour entity.
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