Evidence map›Paper›PMID 38976049›Full record

ReviewEuropean archives of psychiatry and clinical neuroscience2025

Neurosteroids and translocator protein 18 kDa (TSPO) ligands as novel treatment options in depression.

Marco Riebel, Lisa-Marie Brunner, Caroline Nothdurfter, Simon Wein, Jens Schwarzbach, Philippe Liere, Michael Schumacher, Rainer Rupprecht

Abstract readReview
In one paragraph

Review in European archives of psychiatry and clinical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Innovative pharmacological depression treatment.European archives of psychiatry and clinical neuroscience · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marco RiebelDepartment of Psychiatry and Psychotherapy, University Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany. Marco.Riebel@medbo.de.ORCID http://orcid.org/0000-0002-2177-3884
Lisa-Marie BrunnerDepartment of Psychiatry and Psychotherapy, University Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany.
Caroline NothdurfterDepartment of Psychiatry and Psychotherapy, University Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany.
Simon WeinDepartment of Psychiatry and Psychotherapy, University Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany.
Jens SchwarzbachDepartment of Psychiatry and Psychotherapy, University Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany.
Philippe LiereU1195 Inserm and University Paris-Saclay, Le Kremlin-Bicêtre, Paris, 94276, France.
Michael SchumacherU1195 Inserm and University Paris-Saclay, Le Kremlin-Bicêtre, Paris, 94276, France.
Rainer RupprechtDepartment of Psychiatry and Psychotherapy, University Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, the gamma-aminobutyric acid (GABA) system has come into focus for the treatment of anxiety, postpartum depression, and major depressive disorder. Endogenous 3α-reduced steroids such as allopregnanolone are potent positive allosteric modulators of GABA

Indexed as

Antidepressive AgentsDepression, PostpartumMajor Depressive DisorderNeurosteroidsPregnanoloneReceptors, GABAAnimalsbeta-CyclodextrinsDrug CombinationsFemaleHumansLigandsAntidepressive Agentsbeta-CyclodextrinsbrexanoloneDrug CombinationsLigandsNeurosteroidsPregnanoloneReceptors, GABATSPO protein, humanDepressionGABAA receptorNeurosteroidsTreatmentTSPO

Identifiers

PMID38976049
PMCPMC12500809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.