Sirtuin insights: bridging the gap between cellular processes and therapeutic applications.

Shagufta Kamal, Sharon Babar, Waqas Ali, Kanwal Rehman, Amjad Hussain, Muhammad Sajid Hamid Akash

Abstract readReview

In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Mitochondrial Dysfunction in MASLD: Evidence in Dietary Models and Potential Therapeutic Interventions.Biochemistry research international · 2026
Review
From omics to AI-mapping the pathogenic pathways in type 2 diabetes.FEBS letters · 2025
Review
Inflammation and epithelial-mesenchymal transition in a CFTR-depleted human bronchial epithelial cell line revealed by proteomics and human organ-on-a-chip.The FEBS journal · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shagufta KamalDepartment of Biochemistry, Government College University, Faisalabad, Pakistan.

Sharon BabarDepartment of Biochemistry, Government College University, Faisalabad, Pakistan.

Waqas AliDepartment of Biochemistry, Government College University, Faisalabad, Pakistan.

Kanwal RehmanDepartment of Pharmacy, The Women University, Multan, Pakistan.

Amjad HussainInstitute of Chemistry, University of Okara, Okara, Punjab, Pakistan.

Muhammad Sajid Hamid AkashDepartment of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan. sajidakash@gcuf.edu.pk.ORCID http://orcid.org/0000-0002-9446-5233

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The greatest challenges that organisms face today are effective responses or detection of life-threatening environmental changes due to an obvious semblance of stress and metabolic fluctuations. These are associated with different pathological conditions among which cancer is most important. Sirtuins (SIRTs; NAD

Indexed as

NeoplasmsSirtuinsAnimalsHumansMolecular Targeted TherapyPrecision MedicineSirtuinsCancer promoters or suppressorDisease managementSirtuinsTherapeutic intervention

Identifiers

PMID38976046

DOI10.1038/sigtrans.2017.17

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.