Evidence map›Paper›PMID 38976035›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2024

Prospective investigation of amino acid transport and PSMA-targeted positron emission tomography for metastatic lobular breast carcinoma.

Aliza Mushtaq, Ismaheel O Lawal, Saima Muzahir, Sarah C Friend, Manali Bhave, Jane L Meisel, Mylin A Torres, Toncred M Styblo, Cathy L Graham, Kevin Kalinsky and 3 more

Registry-linked trialAbstract readClinical Trial, Phase IClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04750473 (Phase 1 Feasibility Trial), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04750473 phase1completednot on this map

Phase 1 Feasibility Trial: Improved Staging of Lobular Breast Cancer With Novel Amino Acid Metabolic and Tumor Neovasculature Receptor Imaging

TypeinterventionalSponsorEmory UniversityRan2021 to 2024Enrolled20ConditionsAnatomic Stage IV Breast Cancer AJCC v8, Invasive Breast Lobular Carcinoma, Metastatic Breast Lobular Carcinoma, Prognostic Stage IV Breast Cancer AJCC v8ArmsComputed Tomography, Fluciclovine F18, Gallium Ga 68 Gozetotide, Positron Emission Tomography
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Toward targeted therapeutics for lobular breast cancer.The Journal of clinical investigation · 2026
    Review
  3. Imaging the hallmarks of cancer.Nature reviews. Cancer · 2026
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Aliza MushtaqDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, NE, Atlanta, GA, 30322, USA. aliza.mushtaq.21@gmail.com.
Ismaheel O LawalDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, NE, Atlanta, GA, 30322, USA.
Saima MuzahirDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, NE, Atlanta, GA, 30322, USA.
Sarah C FriendDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.
Manali BhaveDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.
Jane L MeiselDepartment of Radiology and Translational Genomics, University of Southern California, Los Angeles, USA.
Mylin A TorresDepartment of Radiation Oncology, Emory University, Atlanta, GA, USA.
Toncred M StybloDepartment of Surgery, Emory University, Atlanta, GA, USA.
Cathy L GrahamDepartment of Surgery, Emory University, Atlanta, GA, USA.
Kevin KalinskyDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.
Jeffrey SwitchenkoDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.
Gary Allan UlanerDepartment of Radiology and Translational Genomics, University of Southern California, Los Angeles, USA.
David M SchusterDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, NE, Atlanta, GA, 30322, USA.

Funding

Improved staging of lobular breast cancer with novel amino acid metabolic and tumor neovasculature receptor imaging.R21CA256280 · NCI · EMORY UNIVERSITY · PI SCHUSTER, DAVID MICHAEL · 2021 to 2022
$362k
Blue Earth Diagnostics Blue Earth DiagnosticsNCI NIH HHS R21 CA256280NIH HHS NIH R21CA256280Telix Pharmaceuticals Telix Pharmaceuticals
6 · The paper itself

Abstract

purposeTo explore the feasibility of imaging amino-acid transport and PSMA molecular pathways in the detection of metastatic breast invasive lobular carcinoma (ILC) and if there is superior detection compared to standard-of-care imaging [computed tomography (CT)/bone scan, or

methods20 women with de-novo or suspected metastatic ILC underwent two PET-CT scans with

resultsThe cDR for standard-of-care imaging was 5/20 patients in 5/60 regions.

conclusionIn this exploratory trial, CLINICAL

trial registrationEarly phase (I-II) clinical trial (NCT04750473) funded by the National Institutes of Health (R21CA256280).

Indexed as

Breast NeoplasmsCarboxylic AcidsCarcinoma, LobularCyclobutanesGallium IsotopesGallium RadioisotopesPositron Emission Tomography Computed TomographyAdultAgedAmino AcidsAntigens, SurfaceBiological TransportEdetic AcidFemaleGlutamate Carboxypeptidase IIHumansAmino AcidsAntigens, SurfaceCarboxylic AcidsCyclobutanesEdetic Acidfluciclovine F-18FOLH1 protein, humangallium 68 PSMA-11Gallium IsotopesGallium RadioisotopesGlutamate Carboxypeptidase IIOligopeptides18F-Fluciclovine68Ga-PSMA-11Detection rateLobular breast cancerPET-CT

Identifiers

PMID38976035
PMCPMC11824347

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.