Evidence map›Paper›PMID 38976029›Full record

ArticleRheumatology international2024

Plasminogen activator inhibitor-1 genotype 4G/5G associates with skin involvement in Armenian familial Mediterranean fever patients.

Gernot Kriegshäuser, Hasmik Hayrapetyan, Christian Oberkanins, Tamara Sarkisian

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Article in Rheumatology international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Gernot KriegshäuserDepartment of Medical Genetics, Yerevan State Medical University, Koryun 2, Yerevan, 0025, Armenia. gernot.kriegshaeuser@ihrlabor.at.ORCID 0000-0003-2768-795X
Hasmik HayrapetyanDepartment of Medical Genetics, Yerevan State Medical University, Koryun 2, Yerevan, 0025, Armenia.ORCID 0000-0003-0162-2680
Christian OberkaninsViennaLab Diagnostics, Vienna, Austria.ORCID 0000-0002-4126-848X
Tamara SarkisianDepartment of Medical Genetics, Yerevan State Medical University, Koryun 2, Yerevan, 0025, Armenia.ORCID 0000-0002-4767-7567

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is little and conflicting data on the role of the plasminogen activator inhibitor-1 (PAI-1, SERPINE1) 4G/5G polymorphism in familial Mediterranean fever (FMF). Therefore this study aimed at evaluating the impact of this polymorphism on the disease course in a cohort of 303 Armenian FMF patients. Genotyping for 12 Mediterranean fever (MEFV) gene mutations and the PAI-1 4G/5G (rs1799762) polymorphism were performed by PCR/reverse-hybridization (StripAssay) and real-time PCR, respectively. PAI-1 genotypes 4G/4G, 4G/5G, and 5G/5G could be identified in 4 (5.88%), 30 (18.63%) and 9 (12.16%) patients with erysipelas-like erythema (ELE), while this was the case for 64 (94.12%), 131 (81.37%), and 65 (87.84%) patients without ELE, respectively (P < 0.033). We have identified a significant relationship between the PAI-1 4G/5G genotype and the occurence of ELE in a relatively large cohort of Armenian FMF patients. Because of conflicting results concerning the impact of this polymorphism on the clinical course of FMF in different populations, further studies are desirable to substantiate the findings reported here.

Indexed as

Familial Mediterranean FeverGenetic Predisposition to DiseaseGenotypePlasminogen Activator Inhibitor 1AdolescentAdultArmeniaCytoskeletal ProteinsErysipelasErythemaFemaleHumansMaleMiddle AgedMutationPolymorphism, GeneticCytoskeletal ProteinsMEFV protein, humanPlasminogen Activator Inhibitor 1PyrinSERPINE1 protein, humanArmeniaFamilial Mediterranean feverGeneticPlasminogen activator inhibitor 1Polymorphism

Identifiers

PMID38976029

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.