ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2024
Association between high risk of obstructive sleep apnea and inflammatory markers in a population sample of young and middle-aged adults in the Miami Heart Study.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Association between hemoglobin and all-cause mortality in patients with obstructive sleep apnea and hypertension: insights from an observational study.Journal of human hypertension · 2026Observational
- Physical activity reduces cancer mortality but not cardiovascular or all-cause mortality in obstructive sleep apnea: a National Health and Nutrition Examination Survey (NHANES)-based analysis.Journal of thoracic disease · 2025Article
- Sex Differences in Predictors of Obstructive Sleep Apnea Risk Among Young Adults: A Cross-Sectional Study in Colombian University Students.Journal of clinical medicine · 2025Article
- Association and risk factors analysis of FeNO and CRP in bronchial asthma combined with obstructive sleep apnea.Frontiers in medicine · 2025Review
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Authors and funding
10 authors.
Funding
Abstract
STUDY
objectivesThere are limited data depicting the association between high risk of obstructive sleep apnea (OSA) and the levels of inflammatory markers in a population-based sample free from cardiovascular disease (CVD). In a large US cohort enriched with a Hispanic population and free of CVD, we aimed to assess the association between high risk of OSA and inflammatory markers.
methodsWe analyzed data for 2,359 clinical CVD-free participants from the Miami Heart Study, aged 40-65 years (May 2015-September 2018). High risk of OSA included those with a high risk using the Berlin Questionnaire. Poisson regression analyses were used to examine the associations between high risk of OSA (reference: low risk of OSA) and high-sensitivity C-reactive protein (hs-CRP), interleukin 6, and tumor necrosis factor alpha levels (continuous) in univariate and multivariate models (adjusting for age, sex, race/ethnicity, and body mass index, diabetes, hypertension, high cholesterol, and smoking).
resultsA total of 552 (28%) participants were categorized as having a high risk of OSA. Patients with a high risk of OSA had higher median values of hs-CRP (2.3 vs 1.0), interleukin 6 (1.9 vs 1.4), and tumor necrosis factor alpha (1.2 vs 1.1) compared with those with a low risk of OSA (all
conclusionsAfter accounting for CVD risk factors, individuals at high risk of OSA had significantly higher levels of hs-CRP, suggesting that OSA screening identified subclinical inflammation in this population sample of individuals free of CVD. CITATION: Khosla AA, Nasir K, Saxena A, et al. Association between high risk of obstructive sleep apnea and inflammatory markers in a population sample of young and middle-aged adults in the Miami Heart Study.
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